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静脉注射蔗糖铁在纠正晚期妊娠孕妇贫血中的作用。

Role of intravenous iron sucrose in correction of anemia in antenatal women with advanced pregnancy.

作者信息

Gupta Avantika, Rathore Asmita Muthal, Manaktala Usha, Gupta Ashutosh, Gupta Sangeeta

机构信息

Department of Obstetrics & Gynaecology, Maulana Azad Medical College, House no. 93-94, Pocket 2, Sector 22, Rohini, New Delhi, 110086 India.

Department of Obstetrics & Gynaecology, Maulana Azad Medical College, New Delhi, India.

出版信息

Indian J Hematol Blood Transfus. 2015 Jun;31(2):251-4. doi: 10.1007/s12288-014-0443-8. Epub 2014 Sep 5.

Abstract

The aim of this study is to observe rise in haematological parameters after treatment with iron sucrose in antenatal patients with moderate anemia with period of gestation 32 to 35 weeks. The study included 45 antenatal patients with period of gestation from 32 to 35 weeks having iron deficiency anemia with haemoglobin levels 7-9 g% and serum ferritin levels less than 12 ng/mL. Intravenous iron sucrose was given in the dose of 200 mg on alternate days, according to the calculated dose. The mean haemoglobin and red blood cell indices were compared on days 7, 14, 21, 28 and at the time of delivery from the baseline value. There was a statistically significant rise in haemoglobin value from baseline on days 14, 21, 28 as well as at the time of delivery (p value <0.0001). The mean rise in haemoglobin values was 0.56 g% on day 14, 1.44 g% on day 21 and 2.0 g% on day 28. At the time of delivery, mean haemoglobin was 11.24 g%. After 28 days of treatment, there was a statistically significant rise in the levels of serum ferritin from 10.33 ± 3.8 ng/mL to 36.89 ± 5.7 ng/mL. Thus, earlier response achieved by iron sucrose can be utilised in the patients presenting at an advanced period of gestation with iron deficiency anemia.

摘要

本研究的目的是观察在妊娠32至35周的中度贫血产前患者中,使用蔗糖铁治疗后血液学参数的升高情况。该研究纳入了45例妊娠32至35周的缺铁性贫血产前患者,其血红蛋白水平为7 - 9 g%,血清铁蛋白水平低于12 ng/mL。根据计算剂量,隔日给予200 mg静脉注射蔗糖铁。在第7天、14天、21天、28天以及分娩时,将平均血红蛋白和红细胞指数与基线值进行比较。在第14天、21天、28天以及分娩时,血红蛋白值相对于基线有统计学显著升高(p值<0.0001)。第14天血红蛋白值平均升高0.56 g%,第21天为1.44 g%,第28天为2.0 g%。分娩时,平均血红蛋白为11.24 g%。治疗28天后,血清铁蛋白水平从10.33±3.8 ng/mL有统计学显著升高至36.89±5.7 ng/mL。因此,蔗糖铁实现的早期反应可用于妊娠晚期出现缺铁性贫血的患者。

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本文引用的文献

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UK guidelines on the management of iron deficiency in pregnancy.英国孕期缺铁管理指南。
Br J Haematol. 2012 Mar;156(5):588-600. doi: 10.1111/j.1365-2141.2011.09012.x.
8
Parenteral iron therapy options.肠外铁剂治疗方案。
Am J Hematol. 2004 May;76(1):74-8. doi: 10.1002/ajh.20056.

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