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心脏神经激素系统的放射性核素成像

Radionuclide imaging of neurohormonal system of the heart.

作者信息

Chen Xinyu, Werner Rudolf A, Javadi Mehrbod S, Maya Yoshifumi, Decker Michael, Lapa Constantin, Herrmann Ken, Higuchi Takahiro

机构信息

1. Devision of Nuclear Medicine, University Hospital of Wuerzburg, Wuerzburg, Germany. ; 2. Comprehensive Heart Failure Center, University Hospital of Wuerzburg, Wuerzburg, Germany.

3. Devision of Nuclear Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA.

出版信息

Theranostics. 2015 Feb 15;5(6):545-58. doi: 10.7150/thno.10900. eCollection 2015.

DOI:10.7150/thno.10900
PMID:25825596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4377725/
Abstract

Heart failure is one of the growing causes of death especially in developed countries due to longer life expectancy. Although many pharmacological and instrumental therapeutic approaches have been introduced for prevention and treatment of heart failure, there are still limitations and challenges. Nuclear cardiology has experienced rapid growth in the last few decades, in particular the application of single photon emission computed tomography (SPECT) and positron emission tomography (PET), which allow non-invasive functional assessment of cardiac condition including neurohormonal systems involved in heart failure; its application has dramatically improved the capacity for fundamental research and clinical diagnosis. In this article, we review the current status of applying radionuclide technology in non-invasive imaging of neurohormonal system in the heart, especially focusing on the tracers that are currently available. A short discussion about disadvantages and perspectives is also included.

摘要

心力衰竭是导致死亡的一个日益增长的原因，尤其是在发达国家，这是由于预期寿命延长所致。尽管已经引入了许多药理学和仪器治疗方法来预防和治疗心力衰竭，但仍然存在局限性和挑战。在过去几十年中，核心脏病学经历了快速发展，特别是单光子发射计算机断层扫描（SPECT）和正电子发射断层扫描（PET）的应用，它们能够对心脏状况进行非侵入性功能评估，包括参与心力衰竭的神经激素系统；其应用极大地提高了基础研究和临床诊断的能力。在本文中，我们回顾了放射性核素技术在心脏神经激素系统非侵入性成像中的应用现状，尤其关注目前可用的示踪剂。还包括对缺点和前景的简短讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4827/4377725/bfd0d5a86ccc/thnov05p0545g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4827/4377725/bfd0d5a86ccc/thnov05p0545g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4827/4377725/8642211bc260/thnov05p0545g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4827/4377725/e419311c94a0/thnov05p0545g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4827/4377725/8b610ea4e13c/thnov05p0545g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4827/4377725/bfd0d5a86ccc/thnov05p0545g009.jpg

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