用于中枢神经系统肾上腺素能受体的正电子发射断层扫描放射性示踪剂：进展与展望。
PET Radiotracers for CNS-Adrenergic Receptors: Developments and Perspectives.
机构信息
University of Missouri Research Reactor, University of Missouri, Columbia, MO 65211-5110, USA.
Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-1013, USA.
出版信息
Molecules. 2020 Sep 3;25(17):4017. doi: 10.3390/molecules25174017.
Epinephrine (E) and norepinephrine (NE) play diverse roles in our body's physiology. In addition to their role in the peripheral nervous system (PNS), E/NE systems including their receptors are critical to the central nervous system (CNS) and to mental health. Various antipsychotics, antidepressants, and psychostimulants exert their influence partially through different subtypes of adrenergic receptors (ARs). Despite the potential of pharmacological applications and long history of research related to E/NE systems, research efforts to identify the roles of ARs in the human brain taking advantage of imaging have been limited by the lack of subtype specific ligands for ARs and brain penetrability issues. This review provides an overview of the development of positron emission tomography (PET) radiotracers for in vivo imaging of AR system in the brain.
肾上腺素（E）和去甲肾上腺素（NE）在我们身体的生理学中发挥着多样化的作用。除了在外周神经系统（PNS）中的作用外，E/NE 系统及其受体对于中枢神经系统（CNS）和心理健康也至关重要。各种抗精神病药、抗抑郁药和精神兴奋剂通过不同类型的肾上腺素能受体（AR）发挥作用。尽管 E/NE 系统具有潜在的药理学应用和长期的研究历史，但利用成像技术来确定 AR 在人类大脑中的作用的研究工作受到缺乏 AR 亚型特异性配体和脑穿透性问题的限制。这篇综述提供了一种对正电子发射断层扫描（PET）放射性示踪剂在大脑中 AR 系统的体内成像的概述。
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