‡Department of Chemistry, BMC, Uppsala University, SE-751 23 Uppsala, Sweden.
Org Lett. 2015 Apr 17;17(8):1874-7. doi: 10.1021/acs.orglett.5b00551. Epub 2015 Mar 31.
An efficient Pd-catalyzed stereoselective vinyltrifluoromethylation of aryl halides, through decarboxylative cross-coupling with 2-(trifluoromethyl)acrylic acid is described. The ready availability of the starting materials, the high level of functional group tolerance, and excellent E/Z selectivity make this protocol a safe and operationally convenient strategy for efficient synthesis of vinyltrifluoromethyl derivatives.
本文描述了一种高效的钯催化的芳基卤化物的立体选择性乙烯基三氟甲基化反应，通过与 2-（三氟甲基）丙烯酸的脱羧交叉偶联实现。该起始原料易得、官能团容忍度高、E/Z 选择性好，因此该方法是一种安全、操作方便的策略，可用于高效合成乙烯基三氟甲基衍生物。
