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Re-Evaluating Cyclosporine A as a Hair Growth-Promoting Agent in Human Scalp Hair Follicles.

作者信息

Hawkshaw Nathan J, Haslam Iain S, Ansell David M, Shamalak Asim, Paus Ralf

机构信息

Centre for Dermatology Research, Institute of Inflammation and Repair, The University of Manchester, Manchester, UK.

Crown Cosma Clinic, Manchester, UK.

出版信息

J Invest Dermatol. 2015 Aug;135(8):2129-2132. doi: 10.1038/jid.2015.121. Epub 2015 Mar 31.

DOI:10.1038/jid.2015.121
PMID:25826423
Abstract
摘要

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Re-Evaluating Cyclosporine A as a Hair Growth-Promoting Agent in Human Scalp Hair Follicles.重新评估环孢素A作为人头皮毛囊促生长剂的作用
J Invest Dermatol. 2015 Aug;135(8):2129-2132. doi: 10.1038/jid.2015.121. Epub 2015 Mar 31.
2
Inhibitory autocrine factors produced by the mesenchyme-derived hair follicle dermal papilla may be a key to male pattern baldness.间充质来源的毛囊真皮乳头产生的抑制性自分泌因子可能是男性型秃发的关键。
Br J Dermatol. 2006 Apr;154(4):609-18. doi: 10.1111/j.1365-2133.2006.07144.x.
3
Human scalp hair follicles are both a target and a source of prolactin, which serves as an autocrine and/or paracrine promoter of apoptosis-driven hair follicle regression.人类头皮毛囊既是催乳素的作用靶点,也是其来源,催乳素作为一种自分泌和/或旁分泌促进剂,可驱动毛囊凋亡并导致毛囊退化。
Am J Pathol. 2006 Mar;168(3):748-56. doi: 10.2353/ajpath.2006.050468.
4
Interferon-gamma is a potent inducer of catagen-like changes in cultured human anagen hair follicles.干扰素-γ是培养的人类生长期毛囊中退行期样变化的强效诱导剂。
Br J Dermatol. 2005 Apr;152(4):623-31. doi: 10.1111/j.1365-2133.2005.06453.x.
5
Effect of mycophenolic acid on proliferation of dermal papilla cells and induction of anagen hair follicles.霉酚酸对毛乳头细胞增殖及生长期毛囊诱导的影响。
Clin Exp Dermatol. 2015 Dec;40(8):894-902. doi: 10.1111/ced.12650. Epub 2015 Mar 26.
6
Cyclosporine A increases hair follicle growth by suppressing apoptosis-inducing factor nuclear translocation: a new mechanism.环孢素A通过抑制凋亡诱导因子核转位促进毛囊生长:一种新机制。
Fundam Clin Pharmacol. 2015 Apr;29(2):191-203. doi: 10.1111/fcp.12100. Epub 2015 Mar 8.
7
T-oligos as differential modulators of human scalp hair growth and pigmentation: a new "time lapse system" for studying human skin and hair follicle biology in vitro?T-寡核苷酸作为人类头皮毛发生长和色素沉着的差异调节剂:一种用于体外研究人类皮肤和毛囊生物学的新型“延时系统”?
Arch Dermatol Res. 2008 Apr;300(4):155-9. doi: 10.1007/s00403-008-0833-6. Epub 2008 Feb 1.
8
Limitations of human occipital scalp hair follicle organ culture for studying the effects of minoxidil as a hair growth enhancer.用于研究米诺地尔作为毛发生长促进剂效果的人体枕部头皮毛囊器官培养的局限性。
Exp Dermatol. 2004 Oct;13(10):635-42. doi: 10.1111/j.0906-6705.2004.00207.x.
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A hot new twist to hair biology: involvement of vanilloid receptor-1 (VR1/TRPV1) signaling in human hair growth control.毛发生物学的一个热门新进展:香草酸受体-1(VR1/TRPV1)信号传导在人类毛发生长调控中的作用
Am J Pathol. 2005 Apr;166(4):985-98. doi: 10.1016/S0002-9440(10)62320-6.
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Decapeptide with fibroblast growth factor (FGF)-5 partial sequence inhibits hair growth suppressing activity of FGF-5.具有成纤维细胞生长因子(FGF)-5部分序列的十肽可抑制FGF-5的毛发生长抑制活性。
J Cell Physiol. 2003 Nov;197(2):272-83. doi: 10.1002/jcp.10369.

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Cyclosporine A-induced Hair Repigmentation in a Patient with Dermatitis: A Case Report.环孢素A诱导的皮炎患者毛发再色素沉着:一例报告
Oman Med J. 2023 Mar 31;38(2):e491. doi: 10.5001/omj.2023.15. eCollection 2023 Mar.
2
IL-33 Contributes to the Pathological Changes of Hair Follicles in Psoriasis: A Potential Target for Psoriatic Alopecia.白细胞介素-33促成银屑病毛囊的病理变化:银屑病性脱发的一个潜在靶点。
Clin Cosmet Investig Dermatol. 2023 Mar 12;16:639-650. doi: 10.2147/CCID.S403075. eCollection 2023.
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Adiponectin negatively regulates pigmentation, Wnt/β-catenin and HGF/c-Met signalling within human scalp hair follicles ex vivo.

本文引用的文献

1
Cyclosporine A increases hair follicle growth by suppressing apoptosis-inducing factor nuclear translocation: a new mechanism.环孢素A通过抑制凋亡诱导因子核转位促进毛囊生长:一种新机制。
Fundam Clin Pharmacol. 2015 Apr;29(2):191-203. doi: 10.1111/fcp.12100. Epub 2015 Mar 8.
2
Expression of a constitutively active calcineurin encoded by an intron-retaining mRNA in follicular keratinocytes.内含子保留型 mRNA 编码的组成性激活型钙调神经磷酸酶在滤泡角质形成细胞中的表达。
PLoS One. 2011 Mar 14;6(3):e17685. doi: 10.1371/journal.pone.0017685.
3
Interaction of calcineurin with substrates and targeting proteins.
脂联素在体外对人头皮毛囊内的色素沉着、Wnt/β-连环蛋白和HGF/c-Met信号通路起负向调节作用。
Arch Dermatol Res. 2023 Apr;315(3):603-612. doi: 10.1007/s00403-021-02291-2. Epub 2021 Dec 2.
4
Impact of a topical lotion, CG428, on permanent chemotherapy-induced alopecia in breast cancer survivors: a pilot randomized double-blind controlled clinical trial (VOLUME RCT).一种局部外用药 CG428 对乳腺癌幸存者永久性化疗所致脱发的影响:一项随机双盲对照临床试验(VOLUME RCT)。
Support Care Cancer. 2020 Apr;28(4):1829-1837. doi: 10.1007/s00520-019-04982-z. Epub 2019 Jul 23.
5
The Role of Immature and Mature Adipocytes in Hair Cycling.成纤维细胞和成熟脂肪细胞在毛发周期中的作用。
Trends Endocrinol Metab. 2019 Feb;30(2):93-105. doi: 10.1016/j.tem.2018.11.004. Epub 2018 Dec 14.
6
Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles.寻找治疗人类脱发疾病的新策略:环孢素 A 抑制人头皮毛囊真皮乳头中的 Wnt 抑制剂 SFRP1。
PLoS Biol. 2018 May 8;16(5):e2003705. doi: 10.1371/journal.pbio.2003705. eCollection 2018 May.
7
Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2.不同部位人毛囊上皮祖细胞龛的增殖模式存在差异,它们对前列腺素 D2 的反应也存在差异。
Sci Rep. 2017 Nov 9;7(1):15197. doi: 10.1038/s41598-017-15038-9.
8
A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention.《理解化疗引起的脱发及其预防的临床和生物学指南》
Oncologist. 2018 Jan;23(1):84-96. doi: 10.1634/theoncologist.2017-0263. Epub 2017 Sep 26.
9
Advances in Understanding Hair Growth.毛发生长认识的进展
F1000Res. 2016 Feb 8;5. doi: 10.12688/f1000research.7520.1. eCollection 2016.
钙调神经磷酸酶与底物和靶向蛋白的相互作用。
Trends Cell Biol. 2011 Feb;21(2):91-103. doi: 10.1016/j.tcb.2010.09.011. Epub 2010 Nov 4.
4
Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture.毛发研究方法:如何在人毛囊器官培养中客观地区分生长期和退行期。
Exp Dermatol. 2010 Mar;19(3):305-12. doi: 10.1111/j.1600-0625.2009.00939.x. Epub 2009 Aug 31.
5
NFATc1 balances quiescence and proliferation of skin stem cells.NFATc1平衡皮肤干细胞的静止和增殖。
Cell. 2008 Jan 25;132(2):299-310. doi: 10.1016/j.cell.2007.11.047.
6
NFAT signaling and the invention of vertebrates.NFAT信号传导与脊椎动物的起源
Trends Cell Biol. 2007 Jun;17(6):251-60. doi: 10.1016/j.tcb.2007.04.006. Epub 2007 May 10.
7
Plasticity and cytokinetic dynamics of the hair follicle mesenchyme: implications for hair growth control.毛囊间充质的可塑性和细胞动力学:对毛发生长控制的影响。
J Invest Dermatol. 2003 Jun;120(6):895-904. doi: 10.1046/j.1523-1747.2003.12237.x.
8
Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes.环孢素A诱导小鼠毛发生长与抑制毛囊角质形成细胞中钙调神经磷酸酶依赖性的NFAT激活有关。
Am J Physiol Cell Physiol. 2003 Jun;284(6):C1593-603. doi: 10.1152/ajpcell.00537.2002.
9
Hair growth control by immunosuppression.通过免疫抑制控制毛发生长
Arch Dermatol Res. 1996 Jun;288(7):408-10. doi: 10.1007/BF02507112.
10
Cyclosporin A prolongs human hair growth in vitro.环孢素A在体外可延长人类毛发的生长。
J Invest Dermatol. 1993 Mar;100(3):237-9. doi: 10.1111/1523-1747.ep12468979.