关于某些二亚胺配体的表面活性剂钴（III）配合物与酵母tRNA的嵌入相互作用的生物物理见解：疏水性的影响。
Biophysical insights into the intercalative interaction of surfactant cobalt(III) complexes of certain diimine ligands bound to yeast tRNA: Effects of hydrophobicity.
作者信息
Nagaraj Karuppiah, Sakthinathan Subramanian, Arunachalam Sankaralingam
机构信息
School of Chemistry, Bharathidasan University, Trichirappalli 620024, Tamilnadu, India.
School of Chemistry, Bharathidasan University, Trichirappalli 620024, Tamilnadu, India.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2015 Aug 5;147:93-8. doi: 10.1016/j.saa.2015.03.042. Epub 2015 Mar 19.
The interaction of two surfactant cobalt(III) complexes, cis-Co(ip)₂(DA)₂₃ 1 and cis-Co(dpq)₂(DA)₂₃ 2 where ip=imidazo[4,5-f][1,10]phenanthroline and dpq=dipyrido[3,2-d:2'-3'-f]quinoxaline with yeast tRNA have been explored by using electronic absorption, competitive binding, electrochemical studies and viscosity measurements. The results suggest that these complexes can bind to tRNA by intercalation. The presence of hydrophobic diimine ligand and the long aliphatic double chains of these complexes facilitate its intercalative interaction with the hydrophobic interior of the tRNA. The extent of tRNA binding of complex 2 has greater affinity than that of complex containing imidazo[4,5-f][1,10]phenanthroline ligands.
通过电子吸收、竞争结合、电化学研究和粘度测量等方法，研究了两种表面活性剂钴（III）配合物顺式-Co(ip)₂(DA)₂₃ 1和顺式-Co(dpq)₂(DA)₂₃ 2（其中ip = 咪唑并[4,5-f][1,10]菲咯啉，dpq = 二吡啶并[3,2-d:2'-3'-f]喹喔啉）与酵母tRNA的相互作用。结果表明，这些配合物可通过插入作用与tRNA结合。这些配合物中疏水性二亚胺配体的存在以及长脂肪族双链促进了其与tRNA疏水内部的插入相互作用。配合物2与tRNA的结合程度比含有咪唑并[4,5-f][1,10]菲咯啉配体的配合物具有更高的亲和力。
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