触发受体表达于髓系细胞2（TREM2）可使小胶质细胞清除β淀粉样蛋白。
TREM2 enables amyloid β clearance by microglia.
作者信息
Rivest Serge
机构信息
Neuroscience Laboratory, CHU de Québec Research Center, Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Blvd., Québec, Canada.
出版信息
Cell Res. 2015 May;25(5):535-6. doi: 10.1038/cr.2015.37. Epub 2015 Mar 31.
Abstract
In a recent paper published in Cell, Wang et al. report that deficiency of triggering receptor expressed on myeloid cells 2 (TREM2) augments amyloid β accumulation and neuronal loss in a mouse model of Alzheimer's disease. TREM2 acts as a signaling receptor involved in innate immunity for the natural clearance of this toxic protein by microglia.
摘要
在最近发表于《细胞》杂志的一篇论文中，王等人报告称，在阿尔茨海默病小鼠模型中，髓样细胞2（TREM2）上表达的触发受体缺乏会加剧淀粉样β蛋白的积累和神经元损失。TREM2作为一种信号受体，参与先天免疫，由小胶质细胞对这种有毒蛋白质进行自然清除。
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