Gussago C, Casati M, Ferri E, Arosio B
Cristina Gussago, PhD, Department of Medical Sciences and Community Health, Università degli Studi di Milano, Via Pace 9, 20122 Milan, Italy phone: +39 0255035405, fax:+39 0250320735, email:
J Frailty Aging. 2019;8(2):54-56. doi: 10.14283/jfa.2018.43.
Alzheimer's disease (AD) is a common neurodegenerative disorder, strongly related with age. It has been reported that genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2), a cell-surface receptor expressed in microglial cells, greatly increase the risk of AD, thus suggesting an involvement of the microglia in the AD pathogenesis. The aim of this report is to provide an overview of the TREM2 and of its possible implication in the pathogenesis of AD.
阿尔茨海默病（AD）是一种常见的神经退行性疾病，与年龄密切相关。据报道，髓样细胞表达的触发受体2（TREM2）的基因变异，TREM2是一种在小胶质细胞中表达的细胞表面受体，会大大增加患AD的风险，因此提示小胶质细胞参与了AD的发病机制。本报告的目的是概述TREM2及其在AD发病机制中的可能作用。
