Fekete K, Györei E, Lohner S, Verduci E, Agostoni C, Decsi T
Department of Biochemistry and Medical Chemistry, University of Pécs, Pécs, Hungary.
Department of Paediatrics, University of Pécs, Pécs, Hungary.
Obes Rev. 2015 Jun;16(6):488-97. doi: 10.1111/obr.12280. Epub 2015 Apr 1.
Long-chain polyunsaturated fatty acid (LCPUFA) status has recently been related to the pathogenesis of obesity. Our aims were to systematically review observational studies investigating LCPUFA status from different blood compartments in overweight or obese subjects and to assess the relationship between LCPUFA profile and obesity. The Ovid MEDLINE, Scopus and Cochrane Library CENTRAL databases were searched from inception to January 2014. The meta-analysis showed significant differences in the LCPUFA composition of total plasma lipids, plasma phospholipids and plasma cholesteryl esters between overweight or obese subjects and controls. Dihomo-γ-linolenic acid (DGLA) values were significantly higher in overweight or obese subjects compared with controls in all the investigated biomarkers. In addition, the DGLA/linoleic acid ratio (surrogate parameter for Δ6 desaturase activity) in plasma phospholipids was significantly elevated (mean difference [MD]: 0.05; 95% confidence interval [CI]: 0.02, 0.08; n = 280), while the arachidonic acid/DGLA ratio (surrogate parameter for Δ5 desaturase activity) was significantly decreased (MD: -0.55; 95% CI: -0.71, -0.39; n = 347) in overweight or obese subjects compared with controls. The results of the present meta-analysis confirm that LCPUFA profile is altered in obesity and suggest that the differences observed in desaturase activities may be responsible for the disturbed LCPUFA metabolism in obesity.
长链多不饱和脂肪酸（LCPUFA）状态最近与肥胖症的发病机制相关。我们的目的是系统回顾观察性研究，这些研究调查超重或肥胖受试者不同血液成分中的LCPUFA状态，并评估LCPUFA谱与肥胖症之间的关系。检索了Ovid MEDLINE、Scopus和Cochrane图书馆CENTRAL数据库，检索时间从建库至2014年1月。荟萃分析显示，超重或肥胖受试者与对照组相比，总血浆脂质、血浆磷脂和血浆胆固醇酯中的LCPUFA组成存在显著差异。在所有研究的生物标志物中，超重或肥胖受试者的二高-γ-亚麻酸（DGLA）值显著高于对照组。此外，血浆磷脂中的DGLA/亚油酸比值（Δ6去饱和酶活性的替代参数）显著升高（平均差[MD]：0.05；95%置信区间[CI]：0.02，0.08；n = 280），而超重或肥胖受试者与对照组相比，花生四烯酸/DGLA比值（Δ5去饱和酶活性的替代参数）显著降低（MD：-0.55；95%CI：-0.71，-0.39；n = 347）。本荟萃分析的结果证实，肥胖症中LCPUFA谱发生改变，并表明去饱和酶活性的差异可能是肥胖症中LCPUFA代谢紊乱的原因。
