利用噬菌体病毒样颗粒平台进行基于表位的疫苗的亲和选择。
Affinity selection of epitope-based vaccines using a bacteriophage virus-like particle platform.
作者信息
O'Rourke John P, Peabody David S, Chackerian Bryce
机构信息
Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131, United States.
Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87131, United States.
出版信息
Curr Opin Virol. 2015 Apr;11:76-82. doi: 10.1016/j.coviro.2015.03.005. Epub 2015 Mar 29.
Abstract
Display of epitopes on virus-like particles (VLPs) is a highly effective technique for enhancing the immunogenicity of antigens that are poorly immunogenic in their native context. VLP-based vaccines can be used to elicit long-lasting, high-titer antibody responses against diverse target antigens, even self-antigens. Most VLP platform-based vaccines are rationally engineered; specific target epitopes or domains are arrayed so that they are displayed at high-valency on the surface of VLPs. In this review, we describe an alternate technique for vaccine discovery using VLPs. This strategy, analogous to filamentous phage display, allows bacteriophage VLP-based vaccines to be identified from a vast library of potential vaccines by affinity selection. This technology integrates epitope discovery and immunization functions into a single platform.
摘要
在病毒样颗粒（VLP）上展示表位是一种高效技术，可增强在天然环境中免疫原性较差的抗原的免疫原性。基于VLP的疫苗可用于引发针对多种靶抗原（甚至自身抗原）的持久、高滴度抗体反应。大多数基于VLP平台的疫苗都是经过合理设计的；特定的靶表位或结构域被排列成在VLP表面高价展示。在本综述中，我们描述了一种使用VLP进行疫苗发现的替代技术。这种策略类似于丝状噬菌体展示，通过亲和选择从大量潜在疫苗库中鉴定基于噬菌体VLP的疫苗。该技术将表位发现和免疫功能整合到一个单一平台中。
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