Vuillermin Peter, Saffery Richard, Allen Katrina J, Carlin John B, Tang Mimi L K, Ranganathan Sarath, Burgner David, Dwyer Terry, Collier Fiona, Jachno Kim, Sly Peter, Symeonides Christos, McCloskey Kathleen, Molloy John, Forrester Michael, Ponsonby Anne-Louise
Barwon Health, Geelong, VIC, Australia, Murdoch Childrens Research Institute, Parkville, VIC, Australia, Deakin University, Geelong, VIC, Australia, University of Melbourne, Parkville, VIC, Australia,
Murdoch Childrens Research Institute, Parkville, VIC, Australia, University of Melbourne, Parkville, VIC, Australia.
Int J Epidemiol. 2015 Aug;44(4):1148-60. doi: 10.1093/ije/dyv026. Epub 2015 Mar 30.
The modern environment is associated with an increasing burden of non-communicable diseases (NCDs). Mounting evidence implicates environmental exposures, experienced early in life (including in utero), in the aetiology of many NCDs, though the cellular/molecular mechanism(s) underlying this elevated risk across the life course remain unclear. Epigenetic variation has emerged as a candidate mediator of such effects. The Barwon Infant Study (BIS) is a population-derived birth cohort study (n = 1074 infants) with antenatal recruitment, conducted in the south-east of Australia (Victoria). BIS has been designed to facilitate a detailed mechanistic investigation of development within an epidemiological framework. The broad objectives are to investigate the role of specific environmental factors, gut microbiota and epigenetic variation in early-life development, and subsequent immune, allergic, cardiovascular, respiratory and neurodevelopmental outcomes. Participants have been reviewed at birth and at 1, 6, 9 and 12 months, with 2- and 4-year reviews under way. Biological samples and measures include: maternal blood, faeces and urine during pregnancy; infant urine, faeces and blood at regular intervals during the first 4 years; lung function at 1 month and 4 years; cardiovascular assessment at 1 month and 4 years; skin-prick allergy testing and food challenge at 1 year; and neurodevelopmental assessment at 9 months, 2 and 4 years. Data access enquiries can be made at [www.barwoninfantstudy.org.au] or via [peter.vuillermin@deakin.edu.au].
现代环境与非传染性疾病（NCDs）负担的增加相关。越来越多的证据表明，生命早期（包括子宫内）经历的环境暴露与许多非传染性疾病的病因有关，尽管这种终生风险增加背后的细胞/分子机制仍不清楚。表观遗传变异已成为这种影响的潜在介导因素。巴旺婴儿研究（BIS）是一项基于人群的出生队列研究（n = 1074名婴儿），在澳大利亚东南部（维多利亚州）进行产前招募。BIS旨在促进在流行病学框架内对发育进行详细的机制研究。其广泛目标是研究特定环境因素、肠道微生物群和表观遗传变异在早期发育中的作用，以及随后的免疫、过敏、心血管、呼吸和神经发育结果。研究人员在婴儿出生时、1个月、6个月、9个月和12个月时进行了评估，目前正在进行2岁和4岁的评估。生物样本和检测包括：孕期母亲的血液、粪便和尿液；婴儿出生后头4年定期采集的尿液、粪便和血液；1个月和4岁时的肺功能；1个月和4岁时的心血管评估；1岁时的皮肤点刺过敏试验和食物激发试验；以及9个月、2岁和4岁时的神经发育评估。可通过[www.barwoninfantstudy.org.au]或[peter.vuillermin@deakin.edu.au]进行数据访问咨询。
