氯胺酮是否靶向大脑中的嗅觉受体？

Does ketamine target olfactory receptors in the brain?

机构信息

Department of Biophysics, Ruhr-University Bochum, 44780 Bochum, Germany. Department of Biophysics, CAS-MPG Partner Institute for Computational Biology, Key Laboratory of Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China.

Department of Cell Physiology, Ruhr-University Bochum, 44780 Bochum, Germany.

出版信息

Sci Signal. 2015 Mar 31;8(370):fs6. doi: 10.1126/scisignal.aab0600.

DOI:10.1126/scisignal.aab0600

PMID:25829445

Abstract

The findings of Ho et al. in this issue of Science Signaling suggest that the anesthetic ketamine binds to and activates select olfactory receptors in mouse brain, raising the possibility that ketamine targets a similar set of GPCRs in humans.

摘要

何等人在本期《科学信号》上的发现表明，麻醉药氯胺酮与小鼠大脑中的特定嗅觉受体结合并激活它们，这增加了氯胺酮可能靶向人类中类似一组 G 蛋白偶联受体的可能性。