Mishra Pankaj Kumar, Khazi Fayaz Mohammed, Yiu Patrick, Billing John Stephen
Department of Cardiothoracic Surgery, Heart and Lung Centre, Wolverhampton, UK
Department of Cardiothoracic Anaesthesia, Heart and Lung Centre, Wolverhampton, UK.
Asian Cardiovasc Thorac Ann. 2016 Jun;24(5):473-6. doi: 10.1177/0218492315577879. Epub 2015 Mar 31.
Antiphospholipid syndrome is an antiphospholipid antibody-mediated prothrombotic state leading to arterial and venous thrombosis. This condition alters routine in-vitro coagulation tests, making results unreliable. Antiphospholipid syndrome patients requiring cardiac surgery with cardiopulmonary bypass present a unique challenge in perioperative anticoagulation management. We describe 3 patients with antiphospholipid syndrome who had successful heart valve surgery at our institution. We have devised an institutional protocol for antiphospholipid syndrome patients, and all 3 patients were managed according to this protocol. An algorithm-based approach is recommended because it improves team work, optimizes treatment, and improves patient outcome.
抗磷脂综合征是一种由抗磷脂抗体介导的血栓前状态，可导致动静脉血栓形成。这种情况会改变常规体外凝血试验，使结果不可靠。需要进行体外循环心脏手术的抗磷脂综合征患者在围手术期抗凝管理方面面临独特挑战。我们描述了3例在我们机构成功进行心脏瓣膜手术的抗磷脂综合征患者。我们为抗磷脂综合征患者制定了一项机构方案，所有3例患者均按照该方案进行管理。建议采用基于算法的方法，因为它能改善团队协作、优化治疗并改善患者预后。
