Farach Andrew, Quesada Jorge, Teh Bin S
1 Department of Radiation Oncology, Baylor College of Medicine, Houston, TX, USA ; 2 Division of Oncology, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA ; 3 Department of Radiation Oncology, Houston Methodist Hospital, Cancer Center and Research Institute, Houston, TX 77030, USA.
J Gastrointest Oncol. 2015 Apr;6(2):E2-6. doi: 10.3978/j.issn.2078-6891.2014.082.
Liver stereotactic body radiation therapy (SBRT) is an emerging treatment option for oligometastases and may confer a survival benefit in select patients. Herein, we document the first case of liver regeneration (LR) following repeat right hepatic lobe SBRT in a woman with breast cancer metastases. Retraction of the treated lobe was significant with a near 50% volume reduction. Compensatory contralateral lobe hypertrophy was noted with a 320% volume increase. The overall liver volume remained stable, within ±5% of baseline. This case indicates that repeat liver SBRT can be delivered safely to individual patients and that compensatory contralateral lobe hypertrophy is observed to maintain a functional liver volume.
肝脏立体定向体部放射治疗（SBRT）是一种针对寡转移瘤的新兴治疗选择，可能会使部分患者受益于生存期延长。在此，我们记录了首例乳腺癌转移女性患者在接受右肝叶重复SBRT后出现肝脏再生（LR）的病例。治疗后的肝叶明显回缩，体积减少近50%。观察到对侧肝叶出现代偿性肥大，体积增加320%。肝脏总体积保持稳定，在基线值的±5%范围内。该病例表明，重复肝脏SBRT可以安全地应用于个体患者，并且观察到对侧肝叶的代偿性肥大可维持肝脏的功能体积。
