Marshalov D V, Shifman E M, Salov I A, Petrenko A P
Anesteziol Reanimatol. 2014 Nov-Dec;59(6):19-23.
Intra-abdomninal pressure (IAP) is one of the reasons for reducing the volume of the subarachnoid space, the cerebrospinal fluid of pregnant iwomnen with obesity and as a result, a high spinal block in spinal anesthesia (SA), clinical manifestation of which is marked arterial hypotension.
To decrease the frequency and severity of arterial hypotension related to the conduct of SA due to the correction dose of local anesthetic with the level of intra-abdomninal pressure and timing of operative delivery
The study involved 252 women. To determine the physiological level of IAP at different stages of gestation used to study the level of IAP in 118 pregnant women with normal body weight. To explore the relationship of frequency of hypotension in the SA and the development of methodology for calculating the dose of local anesthetic in pregnant women examined 92 patients, 62 of whom were obese. To assess the adequacy of the developed technique further examined 42 obese women.
it was determined that the gestation 38-40 weeks, the mean physiological IAP corresponds to 20 mm Hg, at the term of 35-37 weeks - 18 mm Hg at 32-34 weeks of pregnancy - 16 mnm Hg. Studies have shown that an adequate dose of local anesthetic for spinal anesthesia for operative delivery in pregnant women with obesity depends on the level of IAP The required dosage is determined by the percentage reduction for the difference between the actual level of IAP and the predicted IAP The required dosage 5.5% per mm Hg IAP is higher than the physiological norm.
The developed method of calculating the dose of local anesthetic with the levels of IAP and gestational age prevents development of arterial hypertension, the optimum level of sensory block during SA for operative delivery obese women.
腹内压(IAP)是导致蛛网膜下腔空间减小的原因之一,肥胖孕妇的脑脊液会减少,从而导致脊髓麻醉(SA)时出现高位脊髓阻滞,其临床表现为明显的动脉低血压。
通过根据腹内压水平和手术分娩时机调整局部麻醉药的剂量,降低与脊髓麻醉相关的动脉低血压的发生率和严重程度。
该研究纳入了252名女性。为确定妊娠不同阶段的IAP生理水平,对118名体重正常的孕妇进行了IAP水平研究。为探讨脊髓麻醉中低血压的发生率与计算孕妇局部麻醉药剂量方法的发展之间的关系,对92例患者进行了检查,其中62例为肥胖患者。为评估所开发技术的适用性,进一步检查了42例肥胖女性。
确定在妊娠38 - 40周时,平均生理IAP为20 mmHg,在35 - 37周时为18 mmHg,在妊娠32 - 34周时为16 mmHg。研究表明,肥胖孕妇手术分娩时脊髓麻醉的局部麻醉药适当剂量取决于IAP水平。所需剂量由实际IAP水平与预测IAP水平之差的降低百分比确定。每毫米汞柱IAP所需剂量比生理正常值高5.5%。
所开发的根据IAP水平和孕周计算局部麻醉药剂量的方法可预防动脉高血压的发生,为肥胖女性手术分娩时脊髓麻醉提供了最佳的感觉阻滞水平。