Kurimoto Ryota, Sekine Ikuo, Iwasawa Shunichiro, Sakaida Emiko, Tada Yuji, Tatsumi Koichiro, Takahashi Yoko, Nakatani Yukio, Imai Chiaki, Takiguchi Yuichi
Department of Medical Oncology, Graduate School of Medicine, Chiba University, Japan.
Intern Med. 2015;54(7):833-6. doi: 10.2169/internalmedicine.54.3414. Epub 2015 Apr 1.
We herein describe a 67-year-old man with advanced adenocarcinoma of the lung who developed an alveolar hemorrhage (AH) associated with pemetrexed. He received four courses of pemetrexed therapy with carboplatin and seven courses of pemetrexed maintenance therapy. One week after the last pemetrexed administration, the patient developed hemoptysis with deteriorating dyspnea and anemia. Chest images showed diffuse ground-glass attenuation. The diagnosis of AH was based on findings of bloody bronchoalveolar lavage (BAL) fluid, hemosiderin-laden macrophages in the BAL fluid, and a transbronchial lung biopsy sample. This report is the first to describe AH associated with pemetrexed.
我们在此描述一名67岁晚期肺腺癌男性患者，其发生了与培美曲塞相关的肺泡出血（AH）。他接受了四个周期的培美曲塞联合卡铂治疗以及七个周期的培美曲塞维持治疗。在最后一次使用培美曲塞一周后，患者出现咯血，呼吸困难和贫血加重。胸部影像显示弥漫性磨玻璃影。AH的诊断基于血性支气管肺泡灌洗（BAL）液的检查结果、BAL液中含铁血黄素巨噬细胞以及经支气管肺活检样本。本报告首次描述了与培美曲塞相关的AH。
