Yamada Masayuki, Takano Kazuki, Kawai Yuki, Kato Ryoichi
Faculty of Radiological Technology, School of Health Sciences, Fujita Health University.
Magn Reson Med Sci. 2015;14(3):243-50. doi: 10.2463/mrms.2014-0084. Epub 2015 Mar 31.
The use of compact magnetic resonance (MR) systems for the neuroimaging of small animals is spreading. We investigated the potential of such systems in functional MR imaging (fMRI) of somatosensory cortex activity elicited by forepaw stimulation in medetomidine-sedated rats. Using a 1.5-tesla compact imager, we detected maximum activity with an electrophysiologically optimized frequency of 9 Hz in 3 appropriately sedated rats. With this compact system, we successfully mapped neural activity by combining optimum stimulation for a large hemodynamic response with appropriate anesthesia, thus demonstrating the utility of such systems in hemodynamic-based fMRI in preclinical and translational research.
紧凑型磁共振（MR）系统用于小动物神经成像的应用正在不断扩展。我们研究了此类系统在右美托咪定镇静大鼠中，对前爪刺激引发的体感皮层活动进行功能磁共振成像（fMRI）的潜力。使用一台1.5特斯拉的紧凑型成像仪，我们在3只适当镇静的大鼠中，以9赫兹的电生理优化频率检测到了最大活动。借助这个紧凑型系统，我们通过将对大血液动力学反应的最佳刺激与适当麻醉相结合，成功绘制了神经活动图，从而证明了此类系统在临床前和转化研究中基于血液动力学的fMRI中的实用性。
