Zhang Yan, Qiao Chunxia, Li Lian, Zhao Xuye, Li Yali
Department of Gynecology and Obstetrics, the Chinese PLA General Hospital.
Laboratory of Immunology, Institute of Basic Medical Sciences.
Afr Health Sci. 2014 Dec;14(4):913-8. doi: 10.4314/ahs.v14i4.20.
This study measured the human epididymis protein 4 (HE4) and CA125 levels in Chinese women with benign gynecological disorders.
Sera were obtained from Chinese women prior to surgery for a pelvic mass and HE4 and CA125 levels were determined. The proportions of patients with HE4 and CA125 levels were compared.
There were 68 Chinese women with benign diseases. HE4 levels were less elevated than CA125 (1% V.S. 29%, P<0.001). The significant difference was observed in patients with endometriosis/endometriomas in which HE4 was not elevated patients and CA125 was elevated in 53% (P<0.001). Serum HE4 level was not elevated in patients with cystadenoma (0% V.S. 23%, P<0.001) and in patients with germ cell tumors (0% V.S. 5%, P<0.001).
HE4 was less elevated and more suitable as a biomarker than CA125 in chinese women with benign disease.
本研究测定了患有良性妇科疾病的中国女性的附睾蛋白4（HE4）和CA125水平。
采集中国女性盆腔肿块手术前的血清，测定HE4和CA125水平。比较HE4和CA125水平升高的患者比例。
有68名患有良性疾病的中国女性。HE4水平升高的比例低于CA125（1%对29%，P<0.001）。在子宫内膜异位症/子宫内膜瘤患者中观察到显著差异，其中HE4未升高的患者中CA125升高的比例为53%（P<0.001）。囊腺瘤患者（0%对23%，P<0.001）和生殖细胞肿瘤患者（0%对5%，P<0.001）的血清HE4水平未升高。
在患有良性疾病的中国女性中，HE4升高程度较低，比CA125更适合作为生物标志物。
