Kovács György
Interdisciplinary Brachytherapy Unit, University of Lübeck/University Hospital Schleswig-Holstein Campus Lübeck, Germany.
J Contemp Brachytherapy. 2015 Jan;6(4):404-16. doi: 10.5114/jcb.2014.47813. Epub 2014 Dec 31.
Intensity modulated brachytherapy (IMBT) is a modern development of classical interventional radiation therapy (brachytherapy), which allows the application of a high radiation dose sparing severe adverse events, thereby further improving the treatment outcome. Classical indications in head and neck (H&N) cancers are the face, the oral cavity, the naso- and oropharynx, the paranasal sinuses including base of skull, incomplete resections on important structures, and palliation. The application type can be curative, adjuvant or perioperative, as a boost to external beam radiation as well as without external beam radiation and with palliative intention. Due to the frequently used perioperative application method (intraoperative implantation of inactive applicators and postoperative performance of radiation), close interdisciplinary cooperation between surgical specialists (ENT-, dento-maxillary-facial-, neuro- and orbital surgeons), as well interventional radiotherapy (brachytherapy) experts are obligatory. Published results encourage the integration of IMBT into H&N therapy, thereby improving the prognosis and quality of life of patients.
调强近距离放射治疗（IMBT）是传统介入放射治疗（近距离放射治疗）的现代发展，它能够在避免严重不良事件的情况下应用高辐射剂量，从而进一步改善治疗效果。头颈部（H&N）癌症的传统适应证包括面部、口腔、鼻和口咽、包括颅底在内的鼻窦、重要结构的不完全切除以及姑息治疗。应用类型可以是根治性、辅助性或围手术期的，作为外照射放疗的补充，也可以不进行外照射放疗而具有姑息治疗目的。由于常用的围手术期应用方法（术中植入非活性施源器并在术后进行放疗），外科专家（耳鼻喉科、牙颌面外科、神经外科和眼眶外科医生）以及介入放射治疗（近距离放射治疗）专家之间密切的跨学科合作是必不可少的。已发表的结果鼓励将IMBT纳入H&N治疗，从而改善患者的预后和生活质量。
