在雌性食用蛙中植入17β-雌二醇硅橡胶会降低血浆中的甲状腺激素浓度以及肾脏匀浆的体外5'-单脱碘活性。

Estradiol-17 beta silastic implants in female Rana ridibunda depress thyroid hormone concentrations in plasma and the in vitro 5'-monodeiodination activity of kidney homogenates.

作者信息

Vandorpe G, Kühn E R

机构信息

Laboratory of Comparative Endocrinology, Catholic University of Leuven, Belgium.

出版信息

Gen Comp Endocrinol. 1989 Dec;76(3):341-5. doi: 10.1016/0016-6480(89)90127-5.

DOI:10.1016/0016-6480(89)90127-5

PMID:2583466

Abstract

Estradiol-17 beta containing silastic tubings were implanted in female Rana ridibunda. Preliminary data, concerning in vitro incubations of such tubings in saline media, revealed that high concentrations of estradiol were released out of the tubings in the incubation medium. Compared to control-implanted frogs, the frogs that had the estradiol tubings implanted for 30 days showed a significant increase of the plasma estradiol concentration, the ovarian estradiol concentration, and the weight of the oviduct. Plasma triiodothyronine (T3) levels, plasma thyroxine levels, and the in vitro T3 production in the kidney homogenates were significantly decreased. These results indicate that high estradiol levels not only influence the gonadal axis, but also cause important effects on the thyroidal axis.

摘要

将含17β - 雌二醇的硅橡胶管植入雌性食用蛙体内。关于此类硅橡胶管在盐溶液培养基中进行体外培养的初步数据显示，高浓度的雌二醇从硅橡胶管中释放到了培养液中。与植入对照物的青蛙相比，植入雌二醇硅橡胶管30天的青蛙，其血浆雌二醇浓度、卵巢雌二醇浓度以及输卵管重量均显著增加。血浆三碘甲状腺原氨酸（T3）水平、血浆甲状腺素水平以及肾脏匀浆中体外T3生成量均显著降低。这些结果表明，高雌二醇水平不仅影响性腺轴，还会对甲状腺轴产生重要影响。