Melrose J, Ghosh P, Taylor T K
Raymond Purves Research Laboratories (University of Sydney), Royal North Shore Hospital of Sydney, St. Leonards, Australia.
Gerontology. 1989;35(4):173-80. doi: 10.1159/000213019.
Lysozyme was demonstrated to increase in content in the human intervertebral disc in a significant age-dependent manner. In young discs (less than 20 years) the levels were 440 U/g wet weight, whereas in older discs (greater than 65 years) the concentration was 3,460 U/g wet weight. These findings contrasted with the hexuronate level (as a marker of proteoglycans) and neutral sugar content of the tissues which decreased with age. The level of lysozyme determined in the disc tissue also correlated with the morphological grade of disc degeneration.
溶菌酶在人类椎间盘中的含量被证明以显著的年龄依赖性方式增加。在年轻椎间盘（小于20岁）中，水平为440 U/g湿重，而在老年椎间盘（大于65岁）中，浓度为3460 U/g湿重。这些发现与随年龄下降的组织中己糖醛酸水平（作为蛋白聚糖的标志物）和中性糖含量形成对比。在椎间盘组织中测定的溶菌酶水平也与椎间盘退变的形态学分级相关。
