Iwatsuji K, Nakamura S, Kameyama M
Department of Neurology, Kyoto University, Japan.
Gerontology. 1989;35(4):218-24. doi: 10.1159/000213026.
The activity of total and heat-stable glutamate dehydrogenase (GDH) in lymphocytes increased with aging in 40 control subjects (p less than 0.001). The total GDH activity was lower in patients with olivopontocerebellar atrophy (OPCA), motor neuron disease, Parkinson's disease or Alzheimer's disease than in age-matched control subjects, but not in patients with nondegenerative neurological diseases. The decrease in heat-stable GDH activity was observed in patients with OPCA, Parkinson's disease or Alzheimer's disease, but heat-labile GDH was decreased only in patients with OPCA.
40名对照受试者淋巴细胞中总谷氨酸脱氢酶（GDH）和热稳定谷氨酸脱氢酶的活性随年龄增长而增加（p<0.001）。橄榄体脑桥小脑萎缩（OPCA）、运动神经元病、帕金森病或阿尔茨海默病患者的总GDH活性低于年龄匹配的对照受试者，但非退行性神经系统疾病患者并非如此。OPCA、帕金森病或阿尔茨海默病患者观察到热稳定GDH活性降低，但仅OPCA患者的热不稳定GDH降低。
