Zhai Wenlong, Feng Ruo, Wang Haiyu, Wang Yadong
Department of General Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Tumour Biol. 2015 May;36(5):3179-89. doi: 10.1007/s13277-015-3384-4. Epub 2015 Apr 3.
We read with great interest the paper titled "X-ray repair cross-complementing group 1 codon 399 polymorphism and lung cancer risk: an updated meta-analysis" published by Wang et al in Tumor Biology, 2014, 35:411-418. Their results suggest that codon 399 polymorphism of XRCC1 gene might contribute to individual's susceptibility to lung cancer in Asian population and especially in nonsmoking Chinese women. The result is encouraging. Nevertheless, several key issues are worth noticing.
我们饶有兴趣地阅读了王等人于2014年发表在《肿瘤生物学》第35卷第411 - 418页上题为“X射线修复交叉互补基因1第399密码子多态性与肺癌风险：一项更新的荟萃分析”的论文。他们的结果表明，XRCC1基因的第399密码子多态性可能会增加亚洲人群尤其是不吸烟的中国女性患肺癌的易感性。这一结果令人鼓舞。然而，几个关键问题值得注意。
