Kumar Gaurav, Tuli Hardeep Singh, Mittal Sonam, Shandilya Jitendra Kumar, Tiwari Anil, Sandhu Sardul Singh
Department of Biochemistry, Kurukshetra University, Kurukshetra, 136119, India.
Tumour Biol. 2015 Jun;36(6):4005-16. doi: 10.1007/s13277-015-3391-5. Epub 2015 Apr 3.
In recent years, growing interest has been focused on the field of chemoprevention using natural therapies. The reason to turn toward "natural" remedies is associated with diverse beneficial pharmacological properties of natural compounds. Isothiocyanates (ITCs), the major pharmacological active constituents of cruciferous vegetables, are derived from the enzymatic hydrolysis of glucosinolates (GSLs). ITCs govern many intracellular targets including cytochrome P 450 (CYP) enzymes, proteins involved in antioxidant response, tumorigenesis, apoptosis, cell cycle, and metastasis. Investigation of the mechanisms of anti-cancer drugs has given important information regarding the use of natural chemopreventive compounds. This extensive review covers various molecular aspects of the interactions of ITCs with their recognized cellular targets involved in cancer treatment in order to enhance anti-tumor outcome with decreased toxicity to patients.
近年来，人们越来越关注使用天然疗法进行化学预防的领域。转向“天然”疗法的原因与天然化合物多样的有益药理特性有关。异硫氰酸盐（ITCs）是十字花科蔬菜的主要药理活性成分，由硫代葡萄糖苷（GSLs）的酶促水解产生。ITCs作用于许多细胞内靶点，包括细胞色素P 450（CYP）酶、参与抗氧化反应、肿瘤发生、细胞凋亡、细胞周期和转移的蛋白质。对抗癌药物作用机制的研究为天然化学预防化合物的使用提供了重要信息。这篇全面的综述涵盖了ITCs与其在癌症治疗中公认的细胞靶点相互作用的各个分子方面，以提高抗肿瘤效果并降低对患者的毒性。
