Fuhrman B, Brook J G, Aviram M
Harefuah. 1989 Oct;117(7-8):177-81.
Mouse peritoneal macrophages accumulate large amounts of cholesterol ester when incubated with chemically or biologically modified lipoproteins. Incubation of LDL with platelet secretory products for 2 hours at 37 degrees C decreases its protein and cholesterol content. Subsequently this modified LDL, named PCM-LDL, enhances in-vitro platelet aggregation. When it is incubated with cultures of macrophages, cholesterol accumulates in the cells and esterification is increased. PCM-LDL is taken up by macrophages via a receptor-mediated mechanism, independent of the scavenger receptor for acetyl-LDL. Its degradation in lysosomes is required for stimulation of cholesterol ester synthesis.
当与化学修饰或生物修饰的脂蛋白一起孵育时，小鼠腹腔巨噬细胞会积累大量胆固醇酯。将低密度脂蛋白（LDL）与血小板分泌产物在37℃孵育2小时会降低其蛋白质和胆固醇含量。随后，这种经修饰的LDL，即PCM-LDL，会增强体外血小板聚集。当它与巨噬细胞培养物一起孵育时，胆固醇会在细胞中积累且酯化增加。PCM-LDL通过受体介导的机制被巨噬细胞摄取，该机制独立于乙酰化LDL的清道夫受体。其在溶酶体中的降解是刺激胆固醇酯合成所必需的。
