Schlupper-Beckmann J W, Lücke M, Mallmann R
Fortschr Kieferorthop. 1989 Oct;50(5):423-39. doi: 10.1007/BF02171177.
This article describes biochemical relationships accompanying pathological symptoms of C-21-hydroxylase deficiency (adrenogenital syndrome). Disturbances of bone growth and development have been observed, even during medical treatment. A discrepancy of 2 1/2 years was noted between the patients chronological age and his bone development. The patient reaches a maximum height of 155 to 160 cm. Supernumeraries and delayed mineralisation are to be expected. Surgical procedures require an increase in cortisone dosage. When considering orthodontic treatment, one must determine the most appropriate time to start, take into account the long retention period and pay particular attention to oral hygiene.
本文描述了伴有21-羟化酶缺乏（肾上腺生殖器综合征）病理症状的生化关系。即使在药物治疗期间，也观察到了骨骼生长和发育的紊乱。患者的实际年龄与其骨骼发育之间存在2.5年的差异。患者的最大身高为155至160厘米。预计会出现多余牙齿和矿化延迟。外科手术需要增加可的松剂量。在考虑正畸治疗时，必须确定最合适的开始时间，考虑到较长的保持期，并特别注意口腔卫生。
