Morey Jacqueline R, McDevitt Christopher A, Kehl-Fie Thomas E
Research Centre for Infectious Diseases, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA, 5005, Australia.
Biometals. 2015 Jun;28(3):509-19. doi: 10.1007/s10534-015-9850-z. Epub 2015 Apr 3.
During infection invading pathogens must acquire all essential nutrients, including first row transition metals, from the host. To combat invaders, the host exploits this fact and restricts the availability of these nutrients using a defense mechanism known as nutritional immunity. While iron sequestration is the most well-known aspect of this defense, recent work has revealed that the host restricts the availability of other essential elements, notably manganese (Mn), during infection. Furthermore, these studies have revealed that the host utilizes multiple strategies that extend beyond metal sequestration to prevent bacteria from obtaining these metals. This review will discuss the mechanisms by which bacteria attempt to obtain the essential first row transition metal ion Mn during infection, and the approaches utilized by the host to prevent this occurrence. In addition, this review will discuss the impact of host-imposed Mn starvation on invading bacteria.
在感染过程中，入侵的病原体必须从宿主获取所有必需营养素，包括第一排过渡金属。为了对抗入侵者，宿主利用这一事实，并通过一种称为营养免疫的防御机制来限制这些营养素的可用性。虽然铁螯合是这种防御最广为人知的方面，但最近的研究表明，宿主在感染期间会限制其他必需元素的可用性，尤其是锰（Mn）。此外，这些研究还表明，宿主利用多种策略，不仅仅是金属螯合，来阻止细菌获取这些金属。本综述将讨论细菌在感染过程中试图获取必需的第一排过渡金属离子锰的机制，以及宿主用来防止这种情况发生的方法。此外，本综述还将讨论宿主施加的锰饥饿对入侵细菌的影响。
