雌激素和雌激素受体信号通路在癌症和不孕中的作用：以血吸虫为例。
The role of estrogens and estrogen receptor signaling pathways in cancer and infertility: the case of schistosomes.
机构信息
INSA, National Institute of Health Dr. Ricardo Jorge, Porto, Portugal; IPATIMUP, Institute of Pathology and Molecular Immunology of the University of Porto, Portugal.
INSA, National Institute of Health Dr. Ricardo Jorge, Porto, Portugal.
出版信息
Trends Parasitol. 2015 Jun;31(6):246-50. doi: 10.1016/j.pt.2015.03.005. Epub 2015 Mar 30.
Schistosoma haematobium, a parasitic flatworm that infects more than 100 million people, mostly in the developing world, is the causative agent of urogenital schistosomiasis, and is associated with a high incidence of squamous cell carcinoma (SCC) of the bladder. Schistosomiasis haematobia also appears to negatively influence fertility, and is particularly associated with female infertility. Given that estrogens and estrogen receptors are key players in human reproduction, we speculate that schistosome estrogen-like molecules may contribute to infertility through hormonal imbalances. Here, we review recent findings on the role of estrogens and estrogen receptors on both carcinogenesis and infertility associated with urogenital schistosomiasis and discuss the basic hormonal mechanisms that might be common in cancer and infertility.
曼氏血吸虫，一种寄生的扁形虫，感染了超过 1 亿人，主要在发展中国家，是尿路血吸虫病的病原体，并与膀胱鳞状细胞癌（SCC）的高发病率有关。血吸虫病也似乎对生育能力有负面影响，特别是与女性不育有关。鉴于雌激素和雌激素受体是人类生殖的关键因素，我们推测血吸虫雌激素样分子可能通过激素失衡导致不育。在这里，我们回顾了最近关于雌激素和雌激素受体在尿路血吸虫病相关的致癌作用和不育方面的作用的发现，并讨论了可能在癌症和不育中共同存在的基本激素机制。
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