尿生殖型血吸虫病相关膀胱癌研究中的争议和挑战。
Controversies and challenges in research on urogenital schistosomiasis-associated bladder cancer.
机构信息
Stanford Immunology Program and Department of Urology, Stanford University School of Medicine, Stanford, CA, USA.
Department of Pathology, Theodor Bilharz Research Institute, Giza, Egypt.
出版信息
Trends Parasitol. 2014 Jul;30(7):324-32. doi: 10.1016/j.pt.2014.05.004. Epub 2014 Jun 6.
Abstract
Urogenital schistosomiasis, infection with Schistosoma haematobium, is linked to increased risk for the development of bladder cancer, but the importance of various mechanisms responsible for this association remains unclear, in part, owing to lack of sufficient and appropriate animal models. New advances in the study of this parasite, bladder regenerative processes, and human schistosomal bladder cancers may shed new light on the complex biological processes that connect S. haematobium infection to bladder carcinogenesis.
摘要
尿路血吸虫病，即曼氏血吸虫感染，与膀胱癌的发生风险增加相关，但由于缺乏充分和适当的动物模型，导致各种导致这种关联的机制仍不清楚。对这种寄生虫、膀胱再生过程以及人类血吸虫性膀胱癌的研究新进展，可能为连接曼氏血吸虫感染与膀胱癌发生的复杂生物学过程提供新的认识。
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