Kokubo Kenichi, Kurihara Yoshitaka, Tsukao Hiroshi, Maruyama Naoko, Kobayashi Kozue, Shinbo Toshihiro, Hirose Minoru, Kobayashi Hirosuke
Kitasato University Graduate School of Medical Sciences, Sagamihara, Kanagawa, Japan,
J Artif Organs. 2015 Sep;18(3):257-63. doi: 10.1007/s10047-015-0826-0. Epub 2015 Apr 3.
The purpose of the present study was to evaluate the adhesiveness of blood cells and the solute removal performance change of modified polysulfone membranes which have increased polyvinylpyrrolidone (PVP) coverage over their surface. Continuous hemofiltration (CHF) experiments for 24 h were carried out using an ex vivo hemofilter evaluation system to compare a modified polysulfone hemofilter (SHG) with the conventional polysulfone hemofilter (SH). The 25 and 50 % cutoff values of the sieving coefficient of dextran after CHF and the protein concentration in the filtrate was higher in SHG, indicating that less fouling occurred in the SHG membrane. Adhesion of blood cells after 24 h of CHF was significantly higher in the case of SH than in the case of SHG. Blood cell adhesion and membrane fouling were reduced with the use of a polysulfone membrane modified with increased PVP coverage over the surface.
本研究的目的是评估血细胞的粘附性以及表面聚乙烯吡咯烷酮（PVP）覆盖度增加的改性聚砜膜的溶质清除性能变化。使用体外血液滤过器评估系统进行了24小时的持续血液滤过（CHF）实验，以比较改性聚砜血液滤过器（SHG）与传统聚砜血液滤过器（SH）。CHF后葡聚糖筛分系数的25%和50%截留值以及滤液中的蛋白质浓度在SHG中更高，表明SHG膜的污染较少。CHF 24小时后，SH中血细胞的粘附明显高于SHG。使用表面PVP覆盖度增加的改性聚砜膜可减少血细胞粘附和膜污染。
