Tange Yoshihiro, Takesawa Shingo, Yoshitake Shigenori
Department of Medical Engineering, Kyushu University of Health and Welfare, Nobeoka, Miyazaki, Japan.
J Artif Organs. 2017 Dec;20(4):399-402. doi: 10.1007/s10047-017-0971-8. Epub 2017 Jul 6.
Membrane fouling is a primary challenge encountered during the administration of hemodialysis (HD) and hemodiafiltration (HDF). A high-flux membrane is suitable for dialyzer reuse, since it is used repeatedly. Water flux is a benchmark used to assess the effectiveness of the dialysis membrane during treatment and it is usually evaluated to determine whether membrane fouling has occurred. Polysulfone (PS) membrane has good biocompatibility and solute permeability; however, polyethersulfone (PES) is often used as a hemodiafilter membrane because of better hydrophilicity compared to PS. We evaluated water flux across hemodiafilters using newly developed asymmetric triacetate (ATA) and PES as conventional membranes in vitro. Water flux of across ATA and PES membranes significantly decreased 30 min after the start of the experiments and thereafter showed stabilization. Water flux across the ATA membrane consistently showed significantly higher values of greater than 100 mL/m/h/mmHg, compared to lower values observed across the PES membrane. These results suggest that the ATA membrane has a potential use not only for HDF, but also for long-time therapies of HD and HDF.
膜污染是血液透析（HD）和血液透析滤过（HDF）过程中面临的主要挑战。高通量膜适用于透析器复用，因为它可重复使用。水通量是评估治疗期间透析膜有效性的一个基准，通常通过评估水通量来确定是否发生了膜污染。聚砜（PS）膜具有良好的生物相容性和溶质渗透性；然而，聚醚砜（PES）由于比PS具有更好的亲水性，常被用作血液透析滤过膜。我们在体外使用新开发的不对称三醋酸酯（ATA）和作为传统膜的PES评估了血液透析滤过器的水通量。在实验开始30分钟后，ATA和PES膜的水通量显著下降，此后趋于稳定。与PES膜观察到的较低值相比，ATA膜的水通量始终显著高于100 mL/m/h/mmHg。这些结果表明，ATA膜不仅在HDF中具有潜在用途，而且在HD和HDF的长期治疗中也具有潜在用途。
