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独脚金内酯:用于向日葵列当萌发的新型高效独脚金内酯类似物。

Strigolactam: New potent strigolactone analogues for the germination of Orobanche cumana.

作者信息

Lachia Mathilde, Wolf Hanno Christian, Jung Pierre Joseph Marcel, Screpanti Claudio, De Mesmaeker Alain

机构信息

Syngenta Crop Protection AG, Crop Protection Research, Research Chemistry, Schaffhauserstrasse 101, CH-4332 Stein, Switzerland.

Syngenta Crop Protection AG, Crop Protection Research, Research Biology, Schaffhauserstrasse 101, CH-4332 Stein, Switzerland.

出版信息

Bioorg Med Chem Lett. 2015;25(10):2184-8. doi: 10.1016/j.bmcl.2015.03.056. Epub 2015 Mar 26.

Abstract

Very recently, strigolactones have been conclusively identified as phytohormones. The progresses achieved in this field are culminating in the identification of the molecular receptors involved in the signal transduction mechanism. The exact mechanism of the mode of action of strigolactones still remains to be fully elucidated and we were interested to gain some insight into the mechanism of action of strigolactones by selectively modifying the reactivity of the lactone C-ring. Therefore, we report here the synthesis of strigolactams 1 and 16 and their surprisingly good activity on the germination of Orobanche cumana parasitic weed seeds.

摘要

最近,独脚金内酯已被确认为植物激素。该领域取得的进展最终促成了对信号转导机制中涉及的分子受体的鉴定。独脚金内酯的确切作用机制仍有待充分阐明,我们有兴趣通过选择性地改变内酯C环的反应活性来深入了解独脚金内酯的作用机制。因此,我们在此报告独脚金内酰胺1和16的合成及其对列当寄生杂草种子萌发具有惊人的良好活性。

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