†The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, 215004, Jiangsu, China.
§Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, 199 Renai Road, Suzhou Industrial Park, Suzhou, 215123, Jiangsu, China.
ACS Appl Mater Interfaces. 2015 Apr 22;7(15):8033-40. doi: 10.1021/acsami.5b00389. Epub 2015 Apr 10.
Injectable hydrogels are an important class of biomaterials, and they have been widely used for controlled drug release. This study evaluated an injectable hydrogel formed in situ system by the reaction of a polyethylene glycol derivative with α,β-polyaspartylhydrazide for local cancer chemotherapy. This pH-responsive hydrogel was used to realize a sol-gel phase transition, where the gel remained a free-flowing fluid before injection but spontaneously changed into a semisolid hydrogel just after administration. As indicated by scanning electron microscopy images, the hydrogel exhibited a porous three-dimensional microstructure. The prepared hydrogel was biocompatible and biodegradable and could be utilized as a pH-responsive vector for drug delivery. The therapeutic effect of the hydrogel loaded with doxorubicin (DOX) after intratumoral administration in mice with human fibrosarcoma was evaluated. The inhibition of tumor growth was more obvious in the group treated by the DOX-loaded hydrogel, compared to that treated with the free DOX solution. Hence, this hydrogel with good syringeability and high biodegradability, which focuses on local chemotherapy, may enhance the therapeutic effect on human fibrosarcoma.
可注射水凝胶是一类重要的生物材料，已广泛用于控制药物释放。本研究评估了一种原位形成的可注射水凝胶体系，该体系由聚乙二醇衍生物与α,β-聚天冬酰肼反应形成，用于局部癌症化疗。这种 pH 响应水凝胶用于实现溶胶-凝胶相转变，在注射前凝胶保持为自由流动的液体，但在给药后会自发转变为半固体水凝胶。扫描电子显微镜图像表明，水凝胶具有多孔的三维微观结构。所制备的水凝胶具有良好的生物相容性和可生物降解性，可用作 pH 响应药物输送载体。评价了载多柔比星（DOX）水凝胶瘤内给药后在荷人纤维肉瘤小鼠中的治疗效果。与游离 DOX 溶液处理组相比，载 DOX 水凝胶处理组的肿瘤生长抑制更为明显。因此，这种可注射性好、生物降解性高、专注于局部化疗的水凝胶可能会提高对人纤维肉瘤的治疗效果。
