Radha S, Afroz T, Prasad Ch R, Sridhar G, Rajaram K G, Reddy S
Department of Anatomical Pathology and Cytology, Global Hospitals, Hyderabad, Andhra Pradesh, India.
Department of Nephrology, Gandhi Medical College, Secunderabad, Andhra Pradesh, India.
Indian J Nephrol. 2015 Mar-Apr;25(2):82-5. doi: 10.4103/0971-4065.137173.
Recurrence of FSGS in renal allo grafts is a major cause of graft loss. In this context, we tried to diagnose and classify FSGS in renal allografts. Indications for biopsy included graft dysfunction and/or proteinuria. Three hundred and sixty-three graft biopsies were studied over a period of 2 years. We classified FSGS into recurrent FSGS, new-onset primary FSGS and FSGS secondary to chronic humoral rejection, calcineurin inhibitor toxicity, and nephron loss and hyperfiltration injury. Twenty-four cases were diagnosed as FSGS, constituting 6.6%. Secondary FSGS was the most common FSGS in grafts in our study. Incidence of recurrent FSGS may not be accurate as pretransplant biopsy is available in very few cases.
肾移植中局灶节段性肾小球硬化（FSGS）的复发是移植肾丢失的主要原因。在此背景下，我们试图对肾移植中的FSGS进行诊断和分类。活检指征包括移植肾功能不全和/或蛋白尿。在2年的时间里对363例移植肾活检进行了研究。我们将FSGS分为复发性FSGS、新发原发性FSGS以及继发于慢性体液性排斥反应、钙调神经磷酸酶抑制剂毒性、肾单位丢失和超滤损伤的FSGS。24例被诊断为FSGS，占6.6%。在我们的研究中，继发性FSGS是移植肾中最常见的FSGS类型。由于很少有病例进行移植前活检，复发性FSGS的发生率可能不准确。
