Dumas M, d'Athis P, Besancenot J F, Chadoint-Noudeau V, Chalopin J M, Rifle G, Escousse A
Départment de Pharmacologie Clinique, Hopital Général, CHRU, Dijon, France.
Int J Clin Pharmacol Ther Toxicol. 1989 Oct;27(10):486-9.
Decreased elimination of sotalol (160 mg) is found in patients with renal insufficiency. Simulation of plasma concentrations at steady-state exhibits moderately higher concentrations when creatinine clearance is between 10 and 30 ml/min and very high plasma concentrations when creatinine clearance is less than 10 ml/min suggesting, if treatment is absolutely necessary, monitoring in these cases and the reduction of the dose in major renal insufficiency.
在肾功能不全患者中发现索他洛尔（160毫克）的清除率降低。当肌酐清除率在10至30毫升/分钟之间时，稳态血浆浓度模拟显示浓度适度升高；当肌酐清除率低于10毫升/分钟时，血浆浓度非常高，这表明如果绝对有必要进行治疗，在这些情况下需进行监测，并在严重肾功能不全时减少剂量。
