• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Immunohistochemical detection of axillary lymph node micrometastases in node negative breast cancer patients using cytokeratin and epithelial membrane antigen.使用细胞角蛋白和上皮膜抗原对淋巴结阴性乳腺癌患者腋窝淋巴结微转移进行免疫组织化学检测。
South Asian J Cancer. 2015 Jan-Mar;4(1):28-31. doi: 10.4103/2278-330X.149946.
2
Do cytokeratin-positive-only sentinel lymph nodes warrant complete axillary lymph node dissection in patients with invasive breast cancer?仅细胞角蛋白阳性的前哨淋巴结是否需要对浸润性乳腺癌患者进行腋窝淋巴结清扫术？
Am Surg. 2000 Jun;66(6):574-8.
3
Prognostic significance of occult axillary lymph node metastases after chemotherapy-induced pathologic complete response of cytologically proven axillary lymph node metastases from breast cancer.乳腺癌细胞学确诊腋窝淋巴结转移化疗后病理完全缓解后隐匿性腋窝淋巴结转移的预后意义
Cancer. 2009 Apr 15;115(8):1605-12. doi: 10.1002/cncr.24173.
4
Immunohistochemical detection of axillary lymph node micrometastases in breast cancer patients: Increasing the accuracy of detection and decreasing labor intensive serial sectioning.
Indian J Cancer. 2014 July-September;51(3):267-271. doi: 10.4103/0019-509X.146774.
5
[Angiogenesis and micrometastases of regional lymph node in ovarian cancer].
Ai Zheng. 2003 Feb;22(2):185-8.
6
Sentinel node biopsy in ductal carcinoma in situ patients.导管原位癌患者的前哨淋巴结活检
Ann Surg Oncol. 2000 Jan-Feb;7(1):15-20. doi: 10.1007/s10434-000-0015-z.
7
Comparison of CK-IHC assay on serial frozen sections, the OSNA assay, and in combination for intraoperative evaluation of SLN metastases in breast cancer.连续冷冻切片 CK-IHC 检测、OSNA 检测与联合检测在乳腺癌 SLN 术中评估转移中的比较。
Breast Cancer. 2018 Mar;25(2):191-197. doi: 10.1007/s12282-017-0811-y. Epub 2017 Nov 1.
8
Sentinel node biopsy and cytokeratin staining for the accurate staging of 478 breast cancer patients.前哨淋巴结活检及细胞角蛋白染色用于478例乳腺癌患者的准确分期
Am Surg. 1999 Jun;65(6):500-5; discussion 505-6.
9
Characteristics of the sentinel lymph node in breast cancer predict further involvement of higher-echelon nodes in the axilla: a study to evaluate the need for complete axillary lymph node dissection.乳腺癌前哨淋巴结的特征可预测腋窝中更高层级淋巴结的进一步受累情况：一项评估腋窝淋巴结清扫必要性的研究
Arch Surg. 2001 Jun;136(6):688-92. doi: 10.1001/archsurg.136.6.688.
10
Microstaging of breast cancer patients using cytokeratin staining of the sentinel lymph node.利用前哨淋巴结细胞角蛋白染色对乳腺癌患者进行微分期。
Ann Surg Oncol. 1999 Jan-Feb;6(1):95-101. doi: 10.1007/s10434-999-0095-3.

引用本文的文献

1
Prognostic value of isolated tumor cells and micrometastasis of lymph nodes in invasive urinary bladder cancer.浸润性膀胱癌中孤立肿瘤细胞和淋巴结微转移的预后价值。
PLoS One. 2024 Oct 25;19(10):e0302445. doi: 10.1371/journal.pone.0302445. eCollection 2024.
2
Micrometastases in axillary nodes: Out of the reckoning?腋窝淋巴结中的微转移灶：不再考虑了吗？
South Asian J Cancer. 2016 Apr-Jun;5(2):66. doi: 10.4103/2278-330X.181642.

本文引用的文献

1
Comparing touch imprint cytology, frozen section analysis, and cytokeratin immunostaining for intraoperative evaluation of axillary sentinel lymph nodes in breast cancer.比较触摸印片细胞学、冰冻切片分析和细胞角蛋白免疫染色在乳腺癌腋窝前哨淋巴结术中评估中的应用。
Indian J Pathol Microbiol. 2012 Apr-Jun;55(2):183-6. doi: 10.4103/0377-4929.97859.
2
A prospective study comparing touch imprint cytology, frozen section analysis, and rapid cytokeratin immunostain for intraoperative evaluation of axillary sentinel lymph nodes in breast cancer.一项前瞻性研究，比较触摸印片细胞学、冰冻切片分析和快速细胞角蛋白免疫染色在乳腺癌腋窝前哨淋巴结术中评估中的应用。
Cancer. 2009 Apr 1;115(7):1555-62. doi: 10.1002/cncr.24182.
3
Bone marrow micrometastasis in breast cancer: review of detection methods, prognostic impact and biological issues.乳腺癌中的骨髓微转移：检测方法、预后影响及生物学问题综述
J Clin Pathol. 2008 May;61(5):570-6. doi: 10.1136/jcp.2007.046649. Epub 2007 Nov 23.
4
Size of breast cancer metastases in axillary lymph nodes: clinical relevance of minimal lymph node involvement.乳腺癌腋窝淋巴结转移灶的大小：微小淋巴结受累的临床意义
J Clin Oncol. 2005 Mar 1;23(7):1379-89. doi: 10.1200/JCO.2005.07.094.
5
Predicting the status of axillary sentinel lymph nodes in 4351 patients with invasive breast carcinoma treated in a single institution.预测在单一机构接受治疗的4351例浸润性乳腺癌患者腋窝前哨淋巴结的状态。
Cancer. 2005 Feb 1;103(3):492-500. doi: 10.1002/cncr.20809.
6
Clinical relevance of reverse transcriptase-polymerase chain reaction for the detection of axillary lymph node metastases in breast cancer.逆转录聚合酶链反应检测乳腺癌腋窝淋巴结转移的临床相关性
Ann Surg Oncol. 2003 Mar;10(2):117-25. doi: 10.1245/aso.2003.01.010.
7
Outcomes of sentinel node biopsy for breast cancer in British Columbia, 1996 to 2001.
Am J Surg. 2003 Feb;185(2):118-26. doi: 10.1016/s0002-9610(02)01215-1.
8
The use of cytokeratin staining in sentinel lymph node biopsy for breast cancer.细胞角蛋白染色在乳腺癌前哨淋巴结活检中的应用。
Am J Surg. 2001 Oct;182(4):330-4. doi: 10.1016/s0002-9610(01)00722-x.
9
Immunohistochemical detection of lymph node metastases in node-negative breast cancer patients.淋巴结阴性乳腺癌患者淋巴结转移的免疫组化检测
Anticancer Res. 2001 Jan-Feb;21(1B):697-9.
10
Role of immunohistochemical detection of lymph-node metastases in management of breast cancer. International Breast Cancer Study Group.免疫组化检测淋巴结转移在乳腺癌管理中的作用。国际乳腺癌研究组。
Lancet. 1999 Sep 11;354(9182):896-900. doi: 10.1016/s0140-6736(98)11104-2.

使用细胞角蛋白和上皮膜抗原对淋巴结阴性乳腺癌患者腋窝淋巴结微转移进行免疫组织化学检测。

Immunohistochemical detection of axillary lymph node micrometastases in node negative breast cancer patients using cytokeratin and epithelial membrane antigen.

作者信息

Choudhury Monisha, Agrawal Sapna, Pujani Mukta, Thomas Shaji, Pujani Meenu

机构信息

Department of Pathology, Lady Hardinge Medical College and Smt. Sucheta Kriplani Hospital, New Delhi, India.

Hamdard Institute of Medical Sciences and Research, New Delhi, India.

出版信息

South Asian J Cancer. 2015 Jan-Mar;4(1):28-31. doi: 10.4103/2278-330X.149946.

DOI:10.4103/2278-330X.149946
PMID:25839017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4382779/
Abstract

BACKGROUND AND OBJECTIVE

The study was conducted to detect occult metastases in lymph node negative breast cancer patients using cytokeratin (CK) and epithelial membrane antigen (EMA) immunohistochemistry (IHC) and correlate this with primary tumor size and grade.

MATERIALS AND METHODS

A total of 32 cases including 12 prospective and 20 retrospective cases of axillary lymph node negative breast cancer were studied. CK and EMA IHC were performed to detect micrometastases.

RESULTS

Axillary lymph node metastases were detected in 18.75% of previously node negative cases using CK and EMA IHC. CK was found to be more sensitive for detection of metastases compared to EMA. A highly significant correlation was observed between tumor grade and axillary lymph node metastases detected by CK and EMA. However, no significant correlation was found between tumor size and axillary lymph node metastases detected by IHC.

CONCLUSION

In the present study, there was an increase of 18.75% in the occult metastases detection rate using CK and EMA. To conclude, IHC detection of occult metastases should be done using CK in all axillary node negative cases, especially in T1 and T2 stage tumors.

摘要

背景与目的

本研究旨在利用细胞角蛋白（CK）和上皮膜抗原（EMA）免疫组化（IHC）检测淋巴结阴性乳腺癌患者的隐匿性转移，并将其与原发肿瘤大小和分级相关联。

材料与方法

共研究了32例病例，包括12例前瞻性和20例回顾性腋窝淋巴结阴性乳腺癌病例。采用CK和EMA免疫组化检测微转移。

结果

使用CK和EMA免疫组化在先前淋巴结阴性的病例中检测到腋窝淋巴结转移的比例为18.75%。发现CK在检测转移方面比EMA更敏感。观察到肿瘤分级与通过CK和EMA检测到的腋窝淋巴结转移之间存在高度显著的相关性。然而，未发现肿瘤大小与通过免疫组化检测到的腋窝淋巴结转移之间存在显著相关性。

结论

在本研究中，使用CK和EMA检测隐匿性转移的比率增加了18.75%。总之，对于所有腋窝淋巴结阴性病例，尤其是T1和T2期肿瘤，应使用CK进行隐匿性转移的免疫组化检测。