Wang Mao-Che, Wang Ying-Piao, Chu Chia-Huei, Tu Tzong-Yang, Shiao An-Suey, Chou Pesus
Department of Otolaryngology Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan ; School of Medicine, National Yang-Ming University, Taipei, Taiwan ; Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan.
Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan ; Department of Otolaryngology Head and Neck Surgery, Mackay Memorial Hospital, Taipei, Taiwan ; Department of Audiology and Speech Language Pathology and School of Medicine, Mackay Medical College, New Taipei City, Taiwan.
ScientificWorldJournal. 2015;2015:248678. doi: 10.1155/2015/248678. Epub 2015 Mar 9.
To investigate the impact of seven-valent pneumococcal conjugate vaccine on tube insertions in a partial immunized pediatric population.
Retrospective ecological study.
This study used Taiwan National Health Insurance Research Database for the period 2000-2009. Every child under 17 years old who received tubes during this 10-year period was identified and analyzed. The tube insertion rates in different age groups and the risk to receive tubes in different birth cohorts before and after the release of the vaccine in 2005 were compared.
The tube insertion rates for children under 17 years of age ranged from 21.6 to 31.9 for 100,000 persons/year. The tube insertion rate of children under 2 years old decreased significantly after 2005 in period effect analysis (β = -0.074, P < 0.05, and the negative β value means a downward trend) and increased in children 2 to 9 years old throughout the study period (positive β values which mean upward trends, P < 0.05). The rate of tube insertion was lower in 2004-2005 and 2006-2007 birth cohorts than that of 2002-2003 birth cohort (RR = 0.90 and 0.21, 95% CI 0.83-0.97 and 0.19-0.23, resp.).
The seven-valent pneumococcal conjugate vaccine may reduce the risk of tube insertion for children of later birth cohorts. The vaccine may have the protective effect on tube insertions in a partial immunized pediatric population.
探讨七价肺炎球菌结合疫苗对部分免疫的儿科人群进行插管的影响。
回顾性生态学研究。
本研究使用了2000 - 2009年台湾国民健康保险研究数据库。确定并分析了在这10年期间接受插管的每一位17岁以下儿童。比较了2005年疫苗发布前后不同年龄组的插管率以及不同出生队列接受插管的风险。
17岁以下儿童的插管率为每年每10万人21.6至31.9例。在时期效应分析中，2005年后2岁以下儿童的插管率显著下降（β = -0.074，P < 0.05，负β值表示下降趋势），而在整个研究期间2至9岁儿童的插管率上升（正β值表示上升趋势，P < 0.05）。2004 - 2005年和2006 - 2007年出生队列的插管率低于2002 - 2003年出生队列（RR分别为0.90和0.21，95%CI分别为0.83 - 0.97和0.19 - 0.2）。
七价肺炎球菌结合疫苗可能降低后期出生队列儿童的插管风险。该疫苗可能对部分免疫的儿科人群的插管具有保护作用。
