多发性梗死性痴呆和阿尔茨海默型痴呆患者的脑干听觉诱发电位

Brainstem auditory evoked potentials in patients with multi-infarct dementia and dementia of the Alzheimer type.

作者信息

Tachibana H, Takeda M, Sugita M

机构信息

Fifth Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

出版信息

Int J Neurosci. 1989 Oct;48(3-4):325-31. doi: 10.3109/00207458909002179.

DOI:10.3109/00207458909002179

PMID:2583949

Abstract

Brainstem auditory evoked potentials (BAEPs) were recorded in 25 patients with multi-infarct dementia (MID) (mean age 71.2 years), 16 patients with dementia of the Alzheimer type (DAT) (mean age 70.6 years), and 34 normal subjects (mean age 69.1 years). Both MID and DAT patients showed significant prolonged interpeak latencies between waves I and V (I-V IPLs) compared to normal subjects (p less than .001 and p less than .01, respectively). In patients with MID, both I-III IPLs and III-V IPLs were significantly longer than those of normal subjects (p less than .01 and p less than .01 respectively). On the other hand, only III-V IPLs were significantly prolonged in patients with DAT (p less than .01). There were no significant differences between MID and DAT with regard to any of the IPLs. Present results suggest that the brainstem lesions are located in the auditory pathways in patients with MID and DAT. However, with BAEP measurements, we were not able to discriminate between patients with MID and DAT.

摘要

对25例多发梗死性痴呆（MID）患者（平均年龄71.2岁）、16例阿尔茨海默型痴呆（DAT）患者（平均年龄70.6岁）和34名正常受试者（平均年龄69.1岁）进行了脑干听觉诱发电位（BAEP）记录。与正常受试者相比，MID和DAT患者的I波与V波之间的峰间期（I-V IPLs）均显著延长（分别为p<0.001和p<0.01）。在MID患者中，I-III IPLs和III-V IPLs均显著长于正常受试者（分别为p<0.01和p<0.01）。另一方面，DAT患者仅III-V IPLs显著延长（p<0.01）。MID和DAT在任何IPLs方面均无显著差异。目前的结果表明，MID和DAT患者的脑干病变位于听觉通路中。然而，通过BAEP测量，我们无法区分MID和DAT患者。