Di Salvo Thomas G
From the Department of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN.
Cardiol Rev. 2015 Sep-Oct;23(5):213-28. doi: 10.1097/CRD.0000000000000071.
Epigenetic regulatory mechanisms play key roles in cardiac development, differentiation, homeostasis, response to stress and injury and disease. Human heart failure epigenetic regulatory mechanisms have not been deciphered to date. This 2-part review distills the rapidly evolving research focused on human heart failure epigenetic regulatory mechanisms. Part I focuses on epigenetic regulatory mechanisms involving RNA, specifically the role of short, intermediate and long noncoding RNAs and endogenous competing RNA regulatory networks. Part II focuses on the epigenetic regulatory mechanisms involving DNA, including DNA methylation, histone modifications, and chromatin conformational changes. Part II concludes with 2 examples of well-studied integrated epigenetic regulatory mechanisms, the structural and functional roles of the mediator complex in regulating transcription, and the epigenetic networked "cross-talk" regulating atrial natriuretic peptide and brain natriuretic peptide promoter activation.
表观遗传调控机制在心脏发育、分化、内环境稳态、应激与损伤反应及疾病过程中发挥着关键作用。迄今为止，人类心力衰竭的表观遗传调控机制尚未被破解。这篇分两部分的综述提炼了围绕人类心力衰竭表观遗传调控机制的快速发展的研究。第一部分聚焦于涉及RNA的表观遗传调控机制，特别是短链、中链和长链非编码RNA以及内源性竞争性RNA调控网络的作用。第二部分聚焦于涉及DNA的表观遗传调控机制，包括DNA甲基化、组蛋白修饰和染色质构象变化。第二部分以两个深入研究的综合表观遗传调控机制的例子作为结尾，即中介体复合物在调节转录中的结构和功能作用，以及调节心房利钠肽和脑利钠肽启动子激活的表观遗传网络“串扰”。
