Darragh Margot, Vanderboor Teresa, Booth Roger J, Sollers John J, Consedine Nathan S
The University of Auckland, New Zealand.
Physiol Behav. 2015 Jun 1;145:45-9. doi: 10.1016/j.physbeh.2015.03.043. Epub 2015 Mar 31.
To investigate placebo effects on heart rate (HR) and heart rate variability (HRV) in recovery from a psychosocial stressor.
A healthy sample underwent two mental arithmetic stress tests in one experimental session. After undergoing the baseline test, participants were randomized into control or placebo groups. Prior to the second stress test, the placebo group received an intranasal dose of 'serotonin' (placebo) with the suggestion that it would enhance recovery. HR and HRV were assessed throughout procedures.
There was an increase in vagally-mediated HRV in the placebo group. The change in HR did not differ between groups.
Placebo suggestion can enhance autonomic recovery after psychosocial stress. Findings are consistent with the notion of top-down mechanisms of placebo effects, but further research would need to specifically examine the role of top-down regulatory pathways as possible mediators of placebo-induced changes in autonomic function.
研究安慰剂对心理社会应激源恢复过程中心率（HR）和心率变异性（HRV）的影响。
一组健康受试者在一次实验环节中接受了两次心算应激测试。在进行基线测试后，参与者被随机分为对照组或安慰剂组。在第二次应激测试前，安慰剂组接受了一剂经鼻给予的“血清素”（安慰剂），并被告知它会促进恢复。在整个过程中对HR和HRV进行评估。
安慰剂组中由迷走神经介导的HRV有所增加。两组之间HR的变化没有差异。
安慰剂暗示可以促进心理社会应激后的自主恢复。研究结果与安慰剂效应的自上而下机制的概念一致，但需要进一步研究来具体检验自上而下的调节通路作为安慰剂诱导的自主功能变化的可能介导者的作用。
