意大利撒丁岛本地山羊和摩弗伦羊脑膜脑炎中加氏隐球菌和新生隐球菌新生变种的遗传和病理特征
Genetic and pathological characteristics of Cryptococcus gattii and Cryptococcus neoformans var. neoformans from meningoencephalitis in autochthonous goats and mouflons, Sardinia, Italy.
作者信息
Maestrale Caterina, Masia Mariangela, Pintus Davide, Lollai Stefano, Kozel Thomas R, Gates-Hollingsworth Marcellene A, Cancedda Maria Giovanna, Cabras Pierangela, Pirino Salvatore, D'Ascenzo Vittoria, Ligios Ciriaco
机构信息
Istituto Zooprofilattico Sperimentale della Sardegna, G.Pegreffi, via Duca degli Abruzzi 8, 07100 Sassari, Italy.
University of Nevada, Reno, NV 89557-0320, USA.
出版信息
Vet Microbiol. 2015 Jun 12;177(3-4):409-13. doi: 10.1016/j.vetmic.2015.03.008. Epub 2015 Mar 17.
In this study, we examined in Sardinia the brain of 555 autochthonous sheep, 50 goats, and 4 mouflons which were found affected by neurological signs. We found 6 goats and one mouflon with meningoencephalitis caused by Cryptococcus sp. There was no evidence of cryptococcal infections in any of the examined sheep. MLST genotyping on Cryptococcus sp. isolates identified Cryptococcus gatti genotype AFLP4/VGI and Cryptococcus neoformans var. neoformans genotype AFLP2/VNIV. Phylogenetically, all Cryptococcus gattii isolates fell within the autochthonous animal, human and environmental Mediterranean isolate cluster, forming a distinct branch along with environmental strains from Alicante, in the southern Mediterranean coast of Spain.
在本研究中，我们在撒丁岛检查了555只当地绵羊、50只山羊和4只摩弗伦羊的大脑，这些动物均表现出神经症状。我们发现6只山羊和1只摩弗伦羊患有由隐球菌属引起的脑膜脑炎。在所检查的绵羊中未发现隐球菌感染的证据。对隐球菌属分离株进行的多位点序列分型鉴定出加氏隐球菌基因型AFLP4/VGI和新生隐球菌新生变种基因型AFLP2/VNIV。在系统发育上，所有加氏隐球菌分离株都属于当地动物、人类和环境中的地中海分离株簇，与来自西班牙地中海沿岸南部阿利坎特的环境菌株一起形成一个独特的分支。
Zotero 插件