新型单光子发射计算机断层显像灌注剂¹²³I-CMICE-013与标准示踪剂相比的血流依赖性摄取

Flow-Dependent Uptake of ¹²³I-CMICE-013, a Novel SPECT Perfusion Agent, Compared with Standard Tracers.

作者信息

Wells R Glenn, Wei Lihui, Petryk Julia, Duan Yin, Marvin Brian, Timmins Rachel, Soueidan Karen, Fernando Pasan, Bensimon Corinne, Ruddy Terrence D

机构信息

Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada Canadian Molecular Imaging Center of Excellence (CMICE), University of Ottawa Heart Institute, Ottawa, Ontario, Canada; and

Canadian Molecular Imaging Center of Excellence (CMICE), University of Ottawa Heart Institute, Ottawa, Ontario, Canada; and Nordion Inc., Ottawa, Ontario, Canada.

出版信息

J Nucl Med. 2015 May;56(5):764-70. doi: 10.2967/jnumed.114.151563. Epub 2015 Apr 3.

DOI:10.2967/jnumed.114.151563

PMID:25840976

Abstract

UNLABELLED

Rotenone derivatives have shown promise in myocardial perfusion imaging (MPI). CMICE-013 is a novel (123)I-labeled rotenone derivative developed for SPECT MPI. The objective of this study was to assess the image quality of CMICE-013 and compare its uptake with tetrofosmin, sestamibi, and (201)Tl in vivo in a porcine model of stress-induced myocardial ischemia.

METHODS

Microspheres were injected simultaneously with the radiotracer injections at rest and stress to measure blood flow. Mimicking a 1-d tetrofosmin protocol, stress imaging used 3 times as much activity and occurred 1 h after the rest injection. SPECT images were obtained at both rest and stress. After imaging, the heart was sectioned into 44-50 pieces. In each heart sample, the tracer uptake was measured in a γ counter. The images were aligned, and the decay-corrected ratio of the signals at rest and stress was used to separate the well-counter signal into rest and stress components. The uptake at rest and stress was compared with microsphere flow measurements.

RESULTS

The CMICE-013 images showed good contrast between the heart and surrounding organs, with heart-to-liver and heart-to-lung uptake ratios similar to those of the standard tracers. Uptake of CMICE-013 was 1.5% of the injected dose at rest and increased more rapidly with increased blood flow than did the standard SPECT tracers. The percentage injected dose of CMICE-013 taken up by the heart was greater (P < 0.05) than (201)Tl, tetrofosmin, or sestamibi at flows greater than 1.5 mL/min/g.

CONCLUSION

CMICE-013 is a promising new SPECT MPI agent.

摘要

未标记

鱼藤酮衍生物在心肌灌注成像（MPI）中已显示出前景。CMICE - 013是一种为单光子发射计算机断层显像（SPECT）心肌灌注成像开发的新型（123）I标记的鱼藤酮衍生物。本研究的目的是评估CMICE - 013的图像质量，并在应激诱导的心肌缺血猪模型中，将其摄取情况与替曲膦、锝[99mTc]甲氧基异丁基异腈和（201）铊在体内进行比较。

方法

在静息和应激状态下注射放射性示踪剂时同时注入微球以测量血流量。模拟1天的替曲膦方案，应激成像使用的活度是静息注射后1小时的3倍。在静息和应激状态下均获取SPECT图像。成像后，将心脏切成44 - 50片。在每个心脏样本中，在γ计数器中测量示踪剂摄取。对图像进行配准，并使用静息和应激状态下信号的衰变校正比值将井型计数器信号分离为静息和应激成分。将静息和应激状态下的摄取情况与微球流量测量结果进行比较。

结果

CMICE - 013图像显示心脏与周围器官之间具有良好的对比度，心脏与肝脏以及心脏与肺的摄取比值与标准示踪剂相似。静息时CMICE - 013的摄取量为注射剂量的1.5%，并且随着血流量增加，其摄取量比标准SPECT示踪剂增加得更快。在血流量大于1.5 mL/min/g时，心脏摄取的CMICE - 013注射剂量百分比大于（201）铊、替曲膦或锝[99mTc]甲氧基异丁基异腈（P < 0.05）。