上胚层和原始内胚层的分化：脆弱的特化确保稳定的决定。
Epiblast and primitive endoderm differentiation: fragile specification ensures stable commitment.
机构信息
Laboratory for Pluripotent Stem Cell Studies, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.
Laboratory for Pluripotent Stem Cell Studies, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan.
出版信息
Cell Stem Cell. 2015 Apr 2;16(4):346-7. doi: 10.1016/j.stem.2015.03.005.
Specification of the epiblast and primitive endoderm is one of the earliest differentiation steps during embryogenesis. In vitro tracking of pluripotency markers in ESCs suggests that epiblast specification may be plastic; however, live imaging of blastocysts, as detailed in a recent paper from Xenopoulos et al (2015), showed that, unlike in ESCs, fate commitment in vivo is largely irreversible.
上胚层和原始内胚层的特化是胚胎发生过程中最早的分化步骤之一。在体外追踪胚胎干细胞中的多能性标记物表明，上胚层特化可能具有可塑性；然而，正如 Xenopoulos 等人（2015 年）的一篇新论文所详细描述的那样，对囊胚进行活体成像表明，与胚胎干细胞不同，体内的命运决定在很大程度上是不可逆转的。
Zotero 插件