Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Egypt.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabuk University, Saudi Arabia.
Eur J Pharmacol. 2015 Jul 5;758:11-5. doi: 10.1016/j.ejphar.2015.03.062. Epub 2015 Apr 3.
Nalbuphine, a kappa-opioid agonist and mu-opioid partial agonist, has been used as an analgesic or an adjuvant with morphine to attenuate the development of morphine dependence and rewarding effect. In this study, we investigated the effect of nalbuphine on tramadol rewarding effect and antinociception. Using the conditioned place preference (CPP) paradigm in mice, we demonstrated that co-administration of nalbuphine (7mg/kg, s.c.) with tramadol (70mg/kg, s.c.) during conditioning completely blocked the CPP induced by tramadol. Co-administration of nalbuphine blocked the increase in dopamine level in the nucleus accumbens induced by tramadol. These actions were accompanied by an increase rather than attenuation of the antinociceptive effect of tramadol. These results suggest that nalbuphine could have a great potential as a pharmacotherapy for tramadol abuse.
纳布啡是一种κ阿片受体激动剂和μ阿片受体部分激动剂，已被用作镇痛剂或与吗啡合用的辅助药物，以减轻吗啡依赖和奖赏效应的发展。在这项研究中，我们研究了纳布啡对曲马多奖赏效应和镇痛作用的影响。使用小鼠条件性位置偏爱（CPP）范式，我们证明，在条件作用期间，纳布啡（7mg/kg，sc）与曲马多（70mg/kg，sc）共同给药完全阻断了曲马多引起的 CPP。纳布啡共同给药阻断了曲马多诱导的伏隔核多巴胺水平的增加。这些作用伴随着曲马多镇痛作用的增强而不是减弱。这些结果表明，纳布啡可能是治疗曲马多滥用的一种有前途的药物治疗方法。
