• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

2-苯甲酰胺基-N-(2,2-二乙氧基乙基)苯甲酰胺的晶体结构

Crystal structure of 2-benzamido-N-(2,2-di-eth-oxy-eth-yl)benzamide.

作者信息

Ouahrouch Abdelaaziz, Taourirte Moha, Lazrek Hassan B, Engels Joachim W, Bolte Michael

机构信息

Laboratory of Bioorganic and Macromolecular Chemistry, Department of Chemistry, Faculty of Sciences and Technology Guéliz (FSTG), BP 549, Marrakech, Morocco.

Laboratory of Biomolecular and Medicinal Chemistry, Department of Chemistry, Faculty of Sciences Semlalia, Marrakech, Morocco.

出版信息

Acta Crystallogr E Crystallogr Commun. 2015 Feb 28;71(Pt 3):o214-5. doi: 10.1107/S2056989015003370. eCollection 2015 Mar 1.

DOI:10.1107/S2056989015003370
PMID:25844255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4350703/
Abstract

In the title compound, C20H24N2O4, both peptide bonds adopt a trans configuration with respect to the -N-H and -C=O groups. The dihedral angle between the aromatic rings is 53.58 (4)°. The mol-ecular conformation is stabilized by an intra-molecular N-H⋯O hydrogen bond. The crystal packing is characterized by zigzag chains of N-H⋯O hydrogen-bonded mol-ecules running along the b-axis direction.

摘要

在标题化合物C₂₀H₂₄N₂O₄中,两个肽键相对于-N-H和-C=O基团均呈反式构型。芳环之间的二面角为53.58 (4)°。分子构象通过分子内N-H⋯O氢键得以稳定。晶体堆积的特征是沿b轴方向由N-H⋯O氢键连接的分子形成锯齿链。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/390e/4350703/c2efab61b2ff/e-71-0o214-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/390e/4350703/d128ea887619/e-71-0o214-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/390e/4350703/c2efab61b2ff/e-71-0o214-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/390e/4350703/d128ea887619/e-71-0o214-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/390e/4350703/c2efab61b2ff/e-71-0o214-fig2.jpg

相似文献

1
Crystal structure of 2-benzamido-N-(2,2-di-eth-oxy-eth-yl)benzamide.2-苯甲酰胺基-N-(2,2-二乙氧基乙基)苯甲酰胺的晶体结构
Acta Crystallogr E Crystallogr Commun. 2015 Feb 28;71(Pt 3):o214-5. doi: 10.1107/S2056989015003370. eCollection 2015 Mar 1.
2
N-[Eth-yl(2-hy-droxy-eth-yl)carbamo-thio-yl]-3-fluoro-benzamide.N- [乙基(2-羟基乙基)氨基甲硫酰基]-3-氟苯甲酰胺
Acta Crystallogr Sect E Struct Rep Online. 2014 Apr 18;70(Pt 5):o570. doi: 10.1107/S1600536814008174. eCollection 2014 May 1.
3
4-[(E)-(4-Eth-oxy-phen-yl)imino-meth-yl]phenol.4-[(E)-(4-乙氧基苯基)亚氨基甲基]苯酚
Acta Crystallogr Sect E Struct Rep Online. 2012 Sep 1;68(Pt 9):o2646. doi: 10.1107/S1600536812034253. Epub 2012 Aug 4.
4
4-[(2-Carb-oxy-eth-yl)amino]-benzoic acid monohydrate.4-[(2-羧基-乙基)氨基]苯甲酸一水合物
Acta Crystallogr Sect E Struct Rep Online. 2012 Apr 1;68(Pt 4):o1098. doi: 10.1107/S1600536812009518. Epub 2012 Mar 17.
5
N-[4-Cyano-3-(trifluoro-meth-yl)phen-yl]-2-eth-oxy-benzamide.N-[4-氰基-3-(三氟甲基)苯基]-2-乙氧基苯甲酰胺
Acta Crystallogr Sect E Struct Rep Online. 2010 Jun 5;66(Pt 7):o1533. doi: 10.1107/S1600536810019811.
6
N-(2,5-Dimeth-oxy-phen-yl)-N'-[4-(2-hy-droxy-eth-yl)phen-yl]urea.N-(2,5-二甲氧基苯基)-N'-[4-(2-羟乙基)苯基]脲
Acta Crystallogr Sect E Struct Rep Online. 2010 Aug 25;66(Pt 9):o2388-9. doi: 10.1107/S1600536810033520.
7
2-But-oxy-N-[2-(diethyl-amino)-eth-yl]quinoline-4-carboxamide (dibucaine).2-丁氧基-N-[2-(二乙氨基)乙基]喹啉-4-甲酰胺(丁卡因)
Acta Crystallogr Sect E Struct Rep Online. 2010 Nov 17;66(Pt 12):o3189. doi: 10.1107/S1600536810045460.
8
2-{4-[Acet-yl(eth-yl)amino]-benzene-sulfonamido}-benzoic acid.2-{4-[乙酰基(乙基)氨基]苯磺酰胺基}苯甲酸
Acta Crystallogr Sect E Struct Rep Online. 2012 May 1;68(Pt 5):o1305. doi: 10.1107/S1600536812013864. Epub 2012 Apr 4.
9
(Z)-Isobutyl 2-benzamido-3-(4-chloro-phen-yl)acrylate.(Z)-2-苯甲酰胺基-3-(4-氯苯基)丙烯酸异丁酯
Acta Crystallogr Sect E Struct Rep Online. 2009 Oct 28;65(Pt 11):o2890. doi: 10.1107/S1600536809043931.
10
2-Eth-oxy-6-{[1-(3-eth-oxy-2-hy-droxy-benz-yl)-1H-benzimidazol-2-yl]meth-yl}phenol nitro-methane monosolvate.2-乙氧基-6-{[1-(3-乙氧基-2-羟基苄基)-1H-苯并咪唑-2-基]甲基}苯酚硝基甲烷单溶剂合物
Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):o1914. doi: 10.1107/S1600536812023665. Epub 2012 May 31.

本文引用的文献

1
Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives.聚卤苯甲腈喹唑啉-4(3H)-酮衍生物的合成及抗菌活性。
Bioorg Med Chem Lett. 2013 Nov 1;23(21):5958-63. doi: 10.1016/j.bmcl.2013.08.068. Epub 2013 Aug 23.
2
Structure validation in chemical crystallography.化学晶体学中的结构验证
Acta Crystallogr D Biol Crystallogr. 2009 Feb;65(Pt 2):148-55. doi: 10.1107/S090744490804362X. Epub 2009 Jan 20.
3
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
4
Synthesis of novel 4,6-disubstituted quinazoline derivatives, their anti-inflammatory and anti-cancer activity (cytotoxic) against U937 leukemia cell lines.新型4,6-二取代喹唑啉衍生物的合成及其对U937白血病细胞系的抗炎和抗癌(细胞毒性)活性。
Eur J Med Chem. 2008 Apr;43(4):846-52. doi: 10.1016/j.ejmech.2007.06.010. Epub 2007 Jul 6.
5
Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas.新型强效口服活性选择性VEGFR-2酪氨酸激酶抑制剂:N-苯基-N'-{4-(4-喹啉氧基)苯基}脲的合成、构效关系及抗肿瘤活性
J Med Chem. 2005 Mar 10;48(5):1359-66. doi: 10.1021/jm030427r.
6
Protein kinase inhibitors as a therapeutic modality.蛋白激酶抑制剂作为一种治疗方式。
Acc Chem Res. 2003 Jun;36(6):462-9. doi: 10.1021/ar0201207.
7
Synthesis and antihyperglycemic activity of suitably functionalized 3H-quinazolin-4-ones.功能化3H-喹唑啉-4-酮的合成及其降血糖活性
Bioorg Med Chem. 2003 May 29;11(11):2439-44. doi: 10.1016/s0968-0896(03)00142-1.
8
Synthesis and antiinflammatory screening of some quinazoline and quinazolyl-4-oxoquinazoline derivatives.某些喹唑啉及喹唑啉基-4-氧代喹唑啉衍生物的合成与抗炎筛选
Arch Pharm (Weinheim). 2002;335(11-12):556-62. doi: 10.1002/ardp.200290009.
9
Synthesis and in vitro antitumor activity of thiophene analogues of 5-chloro-5,8-dideazafolic acid and 2-methyl-2-desamino-5-chloro-5,8-dideazafolic acid.
Bioorg Med Chem. 2002 Jun;10(6):2067-76. doi: 10.1016/s0968-0896(02)00018-4.
10
Studies on disease-modifying antirheumatic drugs: synthesis of novel quinoline and quinazoline derivatives and their anti-inflammatory effect.改善病情抗风湿药物的研究:新型喹啉和喹唑啉衍生物的合成及其抗炎作用。
J Med Chem. 1996 Dec 20;39(26):5176-82. doi: 10.1021/jm9509408.