Miul' E M, Zhil'tsova V M, Biniukov V I
Izv Akad Nauk SSSR Biol. 1989 Sep-Oct(5):766-9.
Hindered phenols, quinones, and SH-compounds have been studied as possible protectors and sensitizers of DNA-protein cross-linking in chromatin. Efficacy of cross-linking was estimated by the quantity of protein linked to DNA after UV irradiation at 254 um in the presence of chemical agents. Phenols and quinones exert protective influence on cross-linking whereas DNA-protein cross-links are sensibilized by cysteine hydrochloride.
受阻酚、醌类化合物和含巯基化合物已作为染色质中DNA-蛋白质交联的潜在保护剂和敏化剂进行了研究。通过在化学试剂存在下于254纳米进行紫外线照射后与DNA相连的蛋白质数量来评估交联效率。酚类和醌类化合物对交联有保护作用，而盐酸半胱氨酸可使DNA-蛋白质交联致敏。
