6-巯基嘌呤重复使用后胰腺炎迅速发展。

Rapid development of pancreatitis following reuse of 6-mercaptopurine.

作者信息

Cappell M S, Das K M

机构信息

Division of Gastroenterology, University of Medicine of New Jersey-Robert Wood Johnson (Rutgers) Medical School, New Brunswick 08903-0019.

出版信息

J Clin Gastroenterol. 1989 Dec;11(6):679-81. doi: 10.1097/00004836-198912000-00017.

DOI:10.1097/00004836-198912000-00017

PMID:2584670

Abstract

A patient with Crohn's disease developed acute pancreatitis 4 h after retaking one 50 mg dose of orally administered 6-mercaptopurine (6-MP). All seven previously reported patients who were rechallenged with 50 mg or more of 6-MP developed pancreatitis within 48 h. These findings suggest that 6-MP can produce pancreatitis due to an idiosyncratic immune-mediated response. Patients with this complication should not reuse 6-MP.

摘要

一名克罗恩病患者在重新服用一剂50毫克口服6-巯基嘌呤（6-MP）4小时后发生急性胰腺炎。先前报告的所有7名再次接受50毫克或更多6-MP治疗的患者均在48小时内发生胰腺炎。这些发现表明，6-MP可因特异质免疫介导反应而导致胰腺炎。有此并发症的患者不应再使用6-MP。