Cappell M S, Das K M
Division of Gastroenterology, University of Medicine of New Jersey-Robert Wood Johnson (Rutgers) Medical School, New Brunswick 08903-0019.
J Clin Gastroenterol. 1989 Dec;11(6):679-81. doi: 10.1097/00004836-198912000-00017.
A patient with Crohn's disease developed acute pancreatitis 4 h after retaking one 50 mg dose of orally administered 6-mercaptopurine (6-MP). All seven previously reported patients who were rechallenged with 50 mg or more of 6-MP developed pancreatitis within 48 h. These findings suggest that 6-MP can produce pancreatitis due to an idiosyncratic immune-mediated response. Patients with this complication should not reuse 6-MP.
一名克罗恩病患者在重新服用一剂50毫克口服6-巯基嘌呤（6-MP）4小时后发生急性胰腺炎。先前报告的所有7名再次接受50毫克或更多6-MP治疗的患者均在48小时内发生胰腺炎。这些发现表明，6-MP可因特异质免疫介导反应而导致胰腺炎。有此并发症的患者不应再使用6-MP。
