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[伴有肺气肿的慢性农民肺疾病]

[Chronic Farmer's lung disease with emphysema].

作者信息

Soumagne T, Degano B, Dalphin J C

机构信息

Service de pneumologie, hôpital Jean-Minjoz, 2, boulevard Fleming, 25030 Besancon cedex, France.

Service d'explorations fonctionnelles de la respiration, de l'exercice et de la dyspnée, hôpital Jean-Minjoz, 2, boulevard Fleming, 25030 Besancon cedex, France.

出版信息

Rev Mal Respir. 2015 Mar;32(3):275-8. doi: 10.1016/j.rmr.2014.04.104. Epub 2014 Aug 5.

Abstract

INTRODUCTION

Farmer's lung (FL) is the most common type of hypersensitivity pneumonitis (HP), with an estimated prevalence of between 0.5 and 1.5% in dairy farmers. In chronic FL, fibrotic sequelae are widely described in the literature although our experience and occasional epidemiological studies emphasize an increased risk of developing emphysema in these patients.

CASE REPORT

We report a case of FL in a 37-year-old patient with typical clinical features (exertional dyspnoea, lymphocytic alveolitis and computed tomography appearances) together with proven allergen exposure. This patient developed early pulmonary emphysema probably due to intermittent massive exposure to antigens and to bacterial and fungal micro-organisms.

CONCLUSION

The current classification of HP differentiates acute, subacute and chronic forms but does not take account of the role of the mode of exposure and the evolution of the disease. The prognosis and evolution of HP seem to be dependent on the type and pattern of exposure. A new classification with two clusters has been suggested: in type 1, massive and intermittent exposure, as in FL, may lead to emphysema with chronic airflow obstruction and, in type 2, chronic exposure to a low level, as in bird fanciers, may lead to fibrosis with a restrictive pattern.

摘要

引言

农民肺(FL)是超敏性肺炎(HP)最常见的类型,据估计在奶农中的患病率为0.5%至1.5%。在慢性FL中,文献广泛描述了纤维化后遗症,尽管我们的经验和偶尔的流行病学研究强调这些患者发生肺气肿的风险增加。

病例报告

我们报告一例37岁FL患者,具有典型临床特征(劳力性呼吸困难、淋巴细胞性肺泡炎和计算机断层扫描表现)且已证实有过敏原暴露。该患者可能由于间歇性大量接触抗原以及细菌和真菌微生物而早期发生了肺气肿。

结论

目前HP的分类区分了急性、亚急性和慢性形式,但未考虑暴露方式和疾病演变的作用。HP的预后和演变似乎取决于暴露的类型和模式。有人提出了一种新的分为两类的分类方法:在第1类中,如在FL中那样大量且间歇性暴露,可能导致伴有慢性气流阻塞的肺气肿,而在第2类中,如在养鸟者中那样长期低水平暴露,可能导致伴有限制性模式的纤维化。

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引用本文的文献

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Emphysema in active farmer's lung disease.
PLoS One. 2017 Jun 14;12(6):e0178263. doi: 10.1371/journal.pone.0178263. eCollection 2017.

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