改善接受抗癫痫药物治疗的女性的叶酸处方情况。

Improving the prescription of folate to women receiving antiepileptic drugs.

作者信息

Sharma Anumeha, Cavitt Jennifer, Privitera Michael, Moseley Brian D

机构信息

Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA.

出版信息

Epilepsy Res. 2015 May;112:27-30. doi: 10.1016/j.eplepsyres.2015.02.004. Epub 2015 Feb 14.

DOI:10.1016/j.eplepsyres.2015.02.004

PMID:25847335

Abstract

In women of childbearing potential (WCP) on antiepileptic drugs (AEDs), there is an increased risk of teratogenicity. This can potentially be reduced with folate supplementation. We evaluated the rate of co-prescription of AEDs and folate to WCP by non-epileptologist Neurology attendings and residents before and after an educational intervention. During the initial 3 month survey, 54 WCP were prescribed ≥1 AEDs. Prior to the intervention, the rate of co-prescription of AEDs and folate was 20.4%. This was higher when neurologists were prescribing AEDs for epilepsy (34.4%) versus other disorders (0%, p=0.02). In the 3 months following the intervention, 48 WCP received AEDs. The rate of co-prescribing folate increased to 64.6% (p<0.001). Neurologists treating epilepsy continued to be more likely to prescribe folate (86.4%) than neurologists treating other conditions (46.2%, p=0.006).

摘要

在服用抗癫痫药物（AEDs）的有生育潜力女性（WCP）中，致畸风险增加。补充叶酸可能会降低这种风险。我们评估了教育干预前后非癫痫专科的神经科主治医生和住院医师对WCP联合开具AEDs和叶酸的比例。在最初的3个月调查期间，54名WCP被开具了≥1种AEDs。在干预之前，AEDs和叶酸的联合开具率为20.4%。当神经科医生为癫痫开具AEDs时，这一比例更高（34.4%），而用于其他疾病时则为0%（p=0.02）。在干预后的3个月里，48名WCP接受了AEDs治疗。叶酸联合开具率增至64.6%（p<0.001）。治疗癫痫的神经科医生继续比治疗其他疾病的神经科医生更有可能开具叶酸（86.4%对46.2%，p=0.006）。