Moura Lidia M V R, Mendez Diego Yacaman, De Jesus Jonathan, Andrade Rogger A, Hoch Daniel B
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
Epilepsy Behav. 2015 Mar;44:151-4. doi: 10.1016/j.yebeh.2014.12.039. Epub 2015 Feb 20.
This study aimed to determine if annual counseling about contraception and pregnancy in the setting of treatment for epilepsy is associated with increased recommending or prescribing of folate.
This is a retrospective cohort study with medical record abstraction. We selected records from 77 women of childbearing age who had two or more visits for epilepsy at a neurology clinic. The assessment included a review of documentation from the first three visits for epilepsy within a 24-month follow-up window. We defined perfect adherence to annual counseling about the impact of epilepsy treatment on contraception or pregnancy as defect-free care for women (DFCW). A recommendation that the patient take over-the-counter folate or a prescription for folate was independently abstracted from the chart at each visit.
The group of patients who received DFCW (N=28, 36.36%) and the group who did not receive DFCW (N=49, 63.63%) were comparable with respect to age, disease duration, baseline history of drug-resistant epilepsy (DRE), presence of concurrent psychiatric disease, epileptologist involvement, number of antiepileptic drugs (AEDs) prescribed, seizure type, and etiology. Twenty (71.4%) patients in the DFCW group and 42 (85.7%) in the non-DFCW group were not recommended or prescribed folic acid (p=0.12).
Even with annual documentation of counseling about how epilepsy treatment may affect contraception and pregnancy, the "action" of prescribing or recommending folic acid during the ensuing 24months is frequently omitted.
本研究旨在确定在癫痫治疗过程中每年进行的避孕和妊娠咨询是否与叶酸推荐或处方的增加有关。
这是一项通过病历摘要进行的回顾性队列研究。我们从77名育龄期女性的病历中选取了她们在神经科诊所因癫痫就诊两次或更多次的记录。评估包括在24个月的随访期内对前三次癫痫就诊记录的审查。我们将对癫痫治疗对避孕或妊娠影响的年度咨询的完美依从定义为女性的无缺陷护理(DFCW)。每次就诊时,从病历中独立提取患者服用非处方叶酸的建议或叶酸处方。
接受DFCW的患者组(N = 28,36.36%)和未接受DFCW的患者组(N = 49,63.63%)在年龄、病程、耐药性癫痫(DRE)的基线病史、并发精神疾病的存在、癫痫专家的参与、开具的抗癫痫药物(AEDs)数量、癫痫发作类型和病因方面具有可比性。DFCW组中有20名(71.4%)患者和非DFCW组中有42名(85.7%)患者未被推荐或开具叶酸(p = 0.12)。
即使每年都有关于癫痫治疗如何影响避孕和妊娠的咨询记录,但在随后的24个月内开具或推荐叶酸的“行动”经常被省略。